Information on EC 3.5.1.109 - sphingomyelin deacylase

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The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.5.1.109
-
RECOMMENDED NAME
GeneOntology No.
sphingomyelin deacylase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a D-glucosyl-N-acylsphingosine + H2O = a fatty acid + D-glucosyl-sphingosine
show the reaction diagram
an N-acyl-sphingosylphosphorylcholine + H2O = a fatty acid + sphingosylphosphorylcholine
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sphingolipid biosynthesis (mammals)
-
-
sphingomyelin metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
N-acyl-sphingosylphosphorylcholine amidohydrolase
The enzyme is involved in the sphingolipid metabolism in the epidermis.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
16-(9-anthroyloxy)hexadecanoyl-sphingosylphosphorylcholine + H2O
16-(9-anthroyloxy)hexadecanoic acid + sphingosylphosphorylcholine
show the reaction diagram
-
-
-
-
?
N-palmitoyl-D-glucosyl-sphingosine + H2O
palmitic acid + D-glucosyl-sphingosine
show the reaction diagram
-
-
-
-
?
N-palmitoyl-D-glucosylsphingosine + H2O
palmitic acid + D-glucosylsphingosine
show the reaction diagram
-
-
-
-
?
N-palmitoyl-sphingosylphosphorylcholine + H2O
palmitic acid + sphingosylphosphorylcholine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no hydrolysis of N-palmitoylsphingosine
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-palmitoyl-D-glucosylsphingosine + H2O
palmitic acid + D-glucosylsphingosine
show the reaction diagram
-
-
-
-
?
N-palmitoyl-sphingosylphosphorylcholine + H2O
palmitic acid + sphingosylphosphorylcholine
show the reaction diagram
-
-
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.7
-
assay at
7.4
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 7
-
pH 4.0: about 35% of maximal activity, pH 7.0: about 70% of maximal activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
in peripheral blood lymphocytes of patients with atopic dermatitis, there is no increase in activity compared with healthy controls
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
-
1 * 40000, SDS-PAGE
42000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 40000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upregulation in epidermis and stratum corneum of patients with atopic dermatitis
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
glucosylceramide sphingomyelin deacylase, is expressed in the skin of patients with atopic dermatitis, which plays an important role in ceramide deficiency (including acylceramides) in the stratum corneum