Literature summary for 3.4.24.B6 extracted from

Shin, M.; Suzuki, M.; Guan, X.; Smith, C.; Bartlett, J.
Murine matrix metalloproteinase-20 overexpression stimulates cell invasion into the enamel layer via enhanced Wnt signaling (2016), Sci. Rep., 6, 29492 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P57748	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ameloblast-lineage cell	specialized cell that deposits tooth enamel	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	in a stably transfected ameloblast-lineage cell line, MMP20 expression promotes cell invasion. Incisors from transgenic mice overexpressing Mmp20 have a striking cell infiltrate which nearly replaces the entire enamel layer. A thin layer of enamel-like material remains over the dentin and at the outer tooth surface, but between these regions are invading fibroblasts and epithelial cells that surround ectopic bone-like calcifications. Overexpressing mice have decreased enamel organ cadherin levels compared to the Mmp20 ablated and wild-type mice, and beta-catenin is predominantly present within the nuclei of invading cells	Mus musculus

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Release 2023.1 (January 2023)