Literature summary for 3.4.24.B28 extracted from

Mattern, J.; Roghi, C.; Hurtz, M.; Knaeuper, V.; Edwards, D.; Poghosyan, Z.
ADAM15 mediates upregulation of claudin-1 expression in breast cancer cells (2019), Sci. Rep., 9, 12540 .

Search for more literature for 3.4.24.B28

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13444	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	expression of ADAM15 natural isoforms in MDA-MB-231 cells leads to cell clustering to varying degree, without changes in epithelial mesenchymal transition markers vimentin, slug and E-cadherin. Expression leads to ADAM15 isoform specific, catalytic function dependent upregulation of claudin-1. The expression of ADAM15A, and to a lesser degree of C and E isoforms leads to an increase in claudin-1 expression in MDA-MB-231 cells, while ADAM15B has no effect. In MCF-7 cells, ADAM15E is the principal variant inducing claudin-1 expression. The PI3K/Akt/mTOR pathway is involved in regulating claudin-1 expression downstream of ADAM15. ADAM15 co-localizes with claudin-1 and ZO1 at cell-cell junctions	Homo sapiens

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Release 2023.1 (January 2023)