Literature summary for 3.4.24.B28 extracted from

Babendreyer, A.; Molls, L.; Simons, I.M.; Dreymueller, D.; Biller, K.; Jahr, H.; Denecke, B.; Boon, R.A.; Bette, S.; Schnakenberg, U.; Ludwig, A.
The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells (2019), J. Mol. Cell. Cardiol., 134, 51-61 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13444	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HPMEC cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	ADAM15 mRNA is up to 4fold upregulated when endothelial cells are exposed to physiologic shear stress	up

General Information

General Information	Comment	Organism
physiological function	ADAM15 mRNA is up to 4fold upregulated when endothelial cells are exposed to physiologic shear stress. This induction is associated with increased presence of ADAM15 protein in the cell lysates and on the surface. Induction of endothelial KLF2 by simvastatin treatment is associated with ADAM15 upregulation. KLF2 overexpression promotes ADAM15 expression under static conditions whereas KLF2 siRNA knockdown prevents ADAM15 induction by shear stress	Homo sapiens

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Release 2023.1 (January 2023)