Application | Comment | Organism |
---|---|---|
medicine | study on the association of ADAM-17 single nucleotide polymorphisms with insulin-resistance phenotypes and obesity risk. G allele carriers at the ADAM17_m1254A > G polymorphism exhibit significantly higher risk of obesity, are shorter, have higher insulin, and lower HDL-C concentrations than AA subjects. For the ADAM17_i33708A > G single nucleotide polymorphism, homozygotes for the A allele display higher risk of obesity, are heavier, have higher body-mass-index and higher waist measurements than GG subjects. There is a significant gene-diet interaction, in which the deleterious association of the i33708A allele with obesity is observed in subjects with low intakes from n-6 polyunsaturated fatty acids, whereas no differences in obesity risk are seen among subjects with high n-6 polyunsaturated fatty acid intake | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | study on the association of ADAM-17 single nucleotide polymorphisms with insulin-resistance phenotypes and obesity risk. G allele carriers at the ADAM17_m1254A > G polymorphism exhibit significantly higher risk of obesity, are shorter, have higher insulin, and lower HDL-C concentrations than AA subjects. For the ADAM17_i33708A > G single nucleotide polymorphism, homozygotes for the A allele display higher risk of obesity, are heavier, have higher body-mass-index and higher waist measurements than GG subjects. There is a significant gene-diet interaction, in which the deleterious association of the i33708A allele with obesity is observed in subjects with low intakes from n-6 polyunsaturated fatty acids, whereas no differences in obesity risk are seen among subjects with high n-6 polyunsaturated fatty acid intake | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |