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Literature summary for 3.4.24.69 extracted from

  • Kull, S.; Schulz, K.M.; Weisemann, J.; Kirchner, S.; Schreiber, T.; Bollenbach, A.; Dabrowski, P.W.; Nitsche, A.; Kalb, S.R.; Dorner, M.B.; Barr, J.R.; Rummel, A.; Dorner, B.G.
    Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype (2015), PLoS ONE, 10, e0116381 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
synaptosome-associated protein SNAP-25 + H2O Clostridium botulinum
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 ?
-
 ?
synaptosome-associated protein SNAP-25 + H2O Clostridium botulinum Chemnitz
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 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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-
-
Clostridium botulinum Chemnitz
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
synaptosome-associated protein SNAP-25 + H2O
-
 Clostridium botulinum ?
-
 ?
synaptosome-associated protein SNAP-25 + H2O
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 Clostridium botulinum Chemnitz ?
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 ?

Synonyms

Synonyms Comment Organism
BoNT/A8
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 Clostridium botulinum
botulinum neurotoxin A8 subtype
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 Clostridium botulinum

General Information

General Information Comment Organism
physiological function The botulinum neurotoxin A8 subtype causes severe botulism. The binding characteristics of the botulinum neurotoxin A8 subtype to its main neuronal protein receptor SV2C are unaffected, whereas binding to membrane-incorporated gangliosides was reduced in comparison to subtype BoNT/A1 Clostridium botulinum