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Literature summary for 3.4.24.69 extracted from
- A capillary electrophoresis method to assay catalytic activity of botulinum neurotoxin serotypes: implications for substrate specificity (2007), Anal. Biochem., 366, 207-217.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | the enzyme can be used as an agent in biowarfare | Clostridium botulinum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SNAP-25 + H2O | Clostridium botulinum | the potent botulinum neurotoxin inhibits neurotransmitter release at cholinergic nerve terminals, causing a descending flaccid paralysis characteristic of the disease botulism | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium botulinum | - |
botulinum light chains of serotypes A, B, E, F, and G | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
development of a rapid quantitative assay method to distiguish the enzyme serotypes A, B, E, F, and G, evaluation, overview | Clostridium botulinum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | development of a rapid assay method to distiguish the enzyme serotypes A, B, E, F, and G, substrate requirements of the different serotypes, overview | Clostridium botulinum | ? | - |
? | |
| SNAP-25 + H2O | the potent botulinum neurotoxin inhibits neurotransmitter release at cholinergic nerve terminals, causing a descending flaccid paralysis characteristic of the disease botulism | Clostridium botulinum | ? | - |
? | |
| SNAP-25 + H2O | i.e. synaptosomal associated protein of 25 kDa, human substrate, substrate peptide fragment products, overview | Clostridium botulinum | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BoNT/A | - |
Clostridium botulinum |
| Botulinum neurotoxin | - |
Clostridium botulinum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
aasay at room temperature | Clostridium botulinum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Clostridium botulinum |
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Release 2023.1 (January 2023)
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