Application | Comment | Organism |
---|---|---|
medicine | remarkably effective drug for treating a wide variety of muscle dysfunctions in humans | Clostridium botulinum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-SNKTRIDEACQRATKML-NH2 | - |
Clostridium botulinum | |
Ac-SNKTRIDEAN(D)CRATKML-NH2 | - |
Clostridium botulinum | |
Ac-SNKTRIDEAN(D)QCRATKML-NH2 | - |
Clostridium botulinum | |
Ac-SNKTRIDEANCRATKML-NH2 | - |
Clostridium botulinum | |
Ac-SNKTRIDEANQCATKML-NH2 | - |
Clostridium botulinum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
Ac-SNKTRIDECNQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
0.59 | - |
Ac-SNKTRIDCANQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
0.89 | - |
Ac-SNKTRIDEANQRCTKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
1.7 | - |
Ac-SNKTRIDEANQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Clostridium botulinum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-SNKTIDEANQRATKML-NH2 + H2O | Clostridium botulinum | synaptosomal protein | Ac-SNKTIDEANQ + RATKML-NH2 | - |
? | |
additional information | Clostridium botulinum | most potent neurotoxin known | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-SNKTIDEANQRATKML-NH2 + H2O | synaptosomal protein | Clostridium botulinum | Ac-SNKTIDEANQ + RATKML-NH2 | - |
? | |
Ac-SNKTRIDCANQRATKML-NH2 + H2O | - |
Clostridium botulinum | Ac-SNKTRIDCANQ + RATKML-NH2 | - |
? | |
Ac-SNKTRIDEANQRATKML-NH2 + H2O | - |
Clostridium botulinum | Ac-SNKTRIDEANQ + RATKML-NH2 | - |
? | |
Ac-SNKTRIDEANQRCTKML-NH2 + H2O | - |
Clostridium botulinum | Ac-SNKTRIDEANQ + RCTKML-NH2 | - |
? | |
Ac-SNKTRIDECNQRATKML + H2O | - |
Clostridium botulinum | ? | - |
? | |
Ac-SNKTRIDECNQRATKML-NH2 + H2O | - |
Clostridium botulinum | Ac-SNKTRIDECNQ + RATKML-NH2 | - |
? | |
additional information | most potent neurotoxin known | Clostridium botulinum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
botox A | - |
Clostridium botulinum |
type A botulinum neurotoxin | - |
Clostridium botulinum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.6 | - |
Ac-SNKTRIDECNQRATKML | pH 7.3, 37°C | Clostridium botulinum | |
23 | - |
Ac-SNKTRIDCANQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
31 | - |
Ac-SNKTRIDEANQRCTKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
47 | - |
Ac-SNKTRIDEANQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
Ac-SNKTRIDEAN(D)CRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
0.11 | - |
Ac-SNKTRIDEANCRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
0.22 | - |
Ac-SNKTRIDEACQRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
0.65 | - |
Ac-SNKTRIDEAN(D)QCRATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum | |
2 | - |
Ac-SNKTRIDEANQCATKML-NH2 | pH 7.3, 37°C | Clostridium botulinum |