Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P41245 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
gelatinase B | - |
Mus musculus |
matrix metalloproteinase-9 | - |
Mus musculus |
MMP-9 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the levels of MMP-9 are increased in the brain and in the peripheral organs after induction of experimental autoimmune encephalomyelitis. After 40 days all the animals recover and do not show signs of experimental autoimmune encephalomyelitis. The absence of MMP-9 in the remission phase suggests a protective role of MMP-9 in the late phase of the disease, because single mmp-9-/- mice present a delayed remission in comparison with wild-type animals suggesting a phase-dependent role of MMP-9 in the disease. MMP-9 levels remain increased in the brains and, to a higher extend, in the spleens of the wild-type mice even during the remission phase, which is in line with the role of MMP-9 as a useful marker and a protective factor for experimental autoimmune encephalomyelitis in the remission phase | up |
General Information | Comment | Organism |
---|---|---|
physiological function | matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis. MMP-9 triggers multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis by the breakdown of the blood-brain barrier | Mus musculus |