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Literature summary for 3.4.23.34 extracted from

  • Kwan, J.C.; Eksioglu, E.A.; Liu, C.; Paul, V.J.; Luesch, H.
    Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation (2009), J. Med. Chem., 52, 5732-5747.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.34

Inhibitors

Inhibitors Comment Organism Structure
grassystatin A potent cathepsin E inhibitor, shows selectivity for cathepsin E over cathepsin D Homo sapiens
grassystatin B potent cathepsin E inhibitor, shows selectivity for cathepsin E over cathepsin D Homo sapiens
grassystatin C potent cathepsin E inhibitor, shows selectivity for cathepsin E over cathepsin D Homo sapiens
pepstatin A
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-
T-lymphocyte CD4+ Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2 + H2O
-
 Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000181
-
-
 Homo sapiens pepstatin A
0.000000354
-
-
 Homo sapiens grassystatin B
0.000000886
-
-
 Homo sapiens grassystatin A
0.0000429
-
-
 Homo sapiens grassystatin C