Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(D)-His-Pro-Phe-His-Leu-PSI(CH2-NH)-Leu-Val-Tyr | i.e. H-77, with reduced isostere as replacement of the-CO-NH- of the peptide bond | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
big ET-2 | - |
Homo sapiens | |
0.009 | - |
big ET-1 | - |
Homo sapiens | |
0.02 | - |
big ET-3 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
big ET-1 + H2O | - |
Homo sapiens | ? | - |
? | |
Human endothelin precursor big ET-1 + H2O | cleavage site: Trp-Val | Homo sapiens | Human endothelin precursor ET-1 + respective C-terminal fragment | - |
? | |
Human endothelin precursor big ET-2 + H2O | cleavage site: Trp-Val | Homo sapiens | Human endothelin precursor ET-2 + respective C-terminal fragment | - |
? | |
Human endothelin precursor big ET-3 + H2O | cleavage site: Trp-Ile | Homo sapiens | Huamn endothelin precursor ET-3 + respective C-terminal fragment | - |
? | |
additional information | no hydrolysis of synthetic peptides corresponding to residues His16-His27 and His16-Ser38 in the big ET-1 sequence | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
big ET-2 | - |
Homo sapiens | |
0.13 | - |
big ET-1 | - |
Homo sapiens | |
0.14 | - |
big ET-3 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.3 | - |
big ET-3 as substrate | Homo sapiens |
3.5 | 4.4 | plateau, big ET-1 and 2 as substrates | Homo sapiens |