Literature summary for 3.4.22.B74 extracted from

Long, Y.; Liu, X.; Wang, N.; Zhou, H.; Zheng, J.
Chloroquine attenuates LPS-mediated macrophage activation through miR-669n-regulated SENP6 protein translation (2015), Am. J. Transl. Res., 7, 2335-2345 .

Search for more literature for 3.4.22.B74

Activating Compound

Activating Compound	Comment	Organism	Structure
Chloroquine	dose-dependently increases SENP6 protein, but not mRNA, in mouse macrophages, RAW264.7 cells. Chloroquine dose-dependently decreases the levels of microRNA-669n, which bound to 3'-UTR of SENP6 mRNA to inhibit its translation	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q6P7W0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Mus musculus	-
RAW-264.7 cell	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	overexpression of SENP6 in RAW264.7 cells significantly decreases the LPS-induced release of proinflammatory proteins, TNF-alpha, IL-6 and IFN-gamma, while depletion of SENP6 in RAW264.7 cells significantly increases these proteins. In LPS-treated RAW264.7 cells, chloroquine dose-dependently decreases the levels of microRNA-669n, which bound to 3'-UTR of SENP6 mRNA to inhibit its translation. Overexpression of microR-669n decreases SENP6, resulting in increased production of TNF-alpha, IL-6 and IFN-gamma in RAW264.7 cells, while depletion of microR-669n increases SENP6	Mus musculus

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Release 2023.1 (January 2023)