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Literature summary for 3.4.22.B73 extracted from

  • Zunino, R.; Schauss, A.; Rippstein, P.; Andrade-Navarro, M.; McBride, H.M.
    The SUMO protease SENP5 is required to maintain mitochondrial morphology and function (2007), J. Cell Sci., 120, 1178-1188.
    View publication on PubMed
Search for more literature for 3.4.22.B73

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O Homo sapiens SENP5 catalyzes the cleavage of SUMO1 from a number of mitochondrial substrates. SENP5 is a new regulator of SUMO1 proteolysis from mitochondrial targets, impacting mitochondrial morphology and metabolism SUMO-1 + mitochondrial fission GTPase DRP1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96HI0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O SENP5 catalyzes the cleavage of SUMO1 from a number of mitochondrial substrates. SENP5 is a new regulator of SUMO1 proteolysis from mitochondrial targets, impacting mitochondrial morphology and metabolism Homo sapiens SUMO-1 + mitochondrial fission GTPase DRP1
-
 ?
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O SENP5 preferentially deSUMOylates SUMO2 and SUMO3 proteins Homo sapiens SUMO-1 + mitochondrial fission GTPase DRP1
-
 ?

Synonyms

Synonyms Comment Organism
SENP5 peptidase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction silencing of SENP5 results in a fragmented and altered morphology Homo sapiens
physiological function SENP5 is a regulator of SUMO1 proteolysis from mitochondrial targets. SENP5 is required to maintain normal mitochondrial morphology and to control intracellular levels of reactive oxygen species. SENP5 expression affects the mitochondrial morphology by increasing the number of cells with elongated tubules Homo sapiens