Information on EC 3.4.22.B73 - SENP5 peptidase

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The expected taxonomic range for this enzyme is: Homo sapiens

EC NUMBER
COMMENTARY hide
3.4.22.B73
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
SENP5 peptidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified target such as Ran GTPase-activating protein 1. Catalyzes desumoylation of mitochondrial fission GTPase DRP1.
show the reaction diagram
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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SUMO conjugation is a dynamic posttranslational modification that can be readily reversed by the activity of sentrin-specific proteases (SENPs). Elevated expression of SENP5 in the failing human hearts, development of cardiomyopathy, overview
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
show the reaction diagram
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-1 + Ran GTPase-activating protein 1
show the reaction diagram
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SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
-
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-2 + Ran GTPase-activating protein 1
show the reaction diagram
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SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
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-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-3 + Ran GTPase-activating protein 1
show the reaction diagram
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SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
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-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
show the reaction diagram
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the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
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-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
show the reaction diagram
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the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
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-
?
SUMOylated dynamin related protein + H2O
dynamin related protein + SUMO
show the reaction diagram
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
show the reaction diagram
SUMOylated dynamin related protein + H2O
dynamin related protein + SUMO
show the reaction diagram
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?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
B23/nucleophosmin
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B23/nucleophosmin physically interacts with SENP3 and SENP5 and regulates their abundance. It thus plays a critical role in controlling the profile of SUMO conjugates within nucleoli through SENP3 and SENP5
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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immunohistochemic enzyme localization analysis, overview
Manually annotated by BRENDA team
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significant increase in the level of enzyme SENP5 in human idiopathic failing hearts
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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SENP5 expression is chiefly detected in the cytoplasm of tumor cells and in the cytoplasm and/or nucleus of normal epithelium cells
Manually annotated by BRENDA team
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in interphase, SenP5 resides primarily within the nucleoli, in addition to a cytosolic pool. Relocalization of SenP5 from the nucleoli to the mitochondrial surface at G2/M transition prior to nuclear envelope breakdown. Transition of SenP5 to the mitochondria plays an important role in mitochondrial fragmentation during mitosis
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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transgenic overexpression of SENP5 in murine cardiomyocytes, overexpression of SENP5 leads to cardiac dysfunction, accompanied by decreased cardiomyocyte proliferation and elevated apoptosis
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C713S
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no isopeptidase activity, no desumoylation of (SUMO-1)-Ran GTPase-activating protein 1 conjugate
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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the SENP5 expression status is associated with differentiation of oral squamous cell carcinoma and not with any other clinicopathological parameters. No detected correlation between SENP5 expression and the degree of epithelial dysplasia in the paracarcinoma epithelium. No expression difference between primary tumors and lymph node metastatic lesions. SENP5 expression is not associated with lymph node metastasis and cumulative survival