Literature summary for 3.4.22.B67 extracted from

Ryu, H.Y.; Wilson, N.R.; Mehta, S.; Hwang, S.S.; Hochstrasser, M.
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy (2016), Genes Dev., 30, 1881-1894 .

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

General Information

General Information	Comment	Organism
physiological function	cells lacking Ulp2 display a twofold increase in transcript levels across chromosome I (ChrI) and ChrXII. This is due to the two chromosomes being present at twice their normal copy number. Extra copies of ChrI and ChrXII appear quickly following loss of active Ulp2 and can be eliminated following reintroduction of Ulp2 gene. Increased dosage of two genes on ChrI-CLN3 and CCR4, encoding a G1-phase cyclin and a subunit of the Ccr4-Not deadenylase complex, respectively, suppresses Ulp2-dependent aneuploidy	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)