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Literature summary for 3.4.22.B67 extracted from
- Emerging roles of desumoylating enzymes (2009), Biochim. Biophys. Acta, 1792, 155-162.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H531A | catalytic-site mutant demonstrates permanent arrest after DNA damage similar to ulp2 deletion mutant | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleoplasm | - |
Saccharomyces cerevisiae | 5654 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polySUMO-protein conjugate + H2O | Saccharomyces cerevisiae | Ulp2 can cleave the SUMO-SUMO linkage in poly-SUMO chains | SUMO + truncated polySUMO-protein conjugate + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P40537 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| polySUMO-protein conjugate + H2O | Ulp2 can cleave the SUMO-SUMO linkage in poly-SUMO chains | Saccharomyces cerevisiae | SUMO + truncated polySUMO-protein conjugate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Smt3-specific protease | - |
Saccharomyces cerevisiae |
| Ulp2 | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in yeast, mutants lacking Ulp2 accumulate high molecular weight SUMO-containing species only in the presence of wild-type Smt3. This is not the case in the smt3 mutants that do not have the critical lysine residues. Ulp2DELTA mutant strains are impaired in the mitotic-specific targeting of the condensin complex to chromatin, in particular rDNA chromatin. In addition, Ulp2 mutants display an increase in premature separation and fail to maintain cohesion at the regions proximal to centromere, which is caused in part by the poor regulation of the SUMO modification status of DNA Topoisomerase II | Saccharomyces cerevisiae |
| physiological function | Ulp2 is required for the maintenance of chromosome structures. Ulp2 is specialized for chain editing activities | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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