Literature summary for 3.4.22.B67 extracted from

Schwartz, D.C.; Felberbaum, R.; Hochstrasser, M.
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint (2007), Mol. Cell. Biol., 27, 6948-6961.

Search for more literature for 3.4.22.B67

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	Ulp2 SUMO protease is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest. It is proposed that one or more proteins is sumoylated following DNA damage-induced checkpoint activation, and this substrate(s) must be desumoylated by Ulp2 for proper cell cycle resumption	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P40537	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Ulp2 SUMO protease is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest. It is proposed that one or more proteins is sumoylated following DNA damage-induced checkpoint activation, and this substrate(s) must be desumoylated by Ulp2 for proper cell cycle resumption	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
Ulp2 SUMO protease	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
malfunction	ulp2DELTA mutants do not show persistent Rad53 phosphorylation following DNA damage, suggesting checkpoint signaling has been terminated and no longer asserts an arrest in these cells. Using Cdc14 localization as a cell cycle indicator, it is shown that nearly half of cells lacking Ulp2 can escape a checkpoint-induced metaphase arrest despite their inability to divide again. Moreover, half of permanently arrested ulp2DELTA cells show evidence of an aberrant mitotic spindle, suggesting that Ulp2 is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest	Saccharomyces cerevisiae
physiological function	Ulp2 is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)