Literature summary for 3.4.22.B66 extracted from

Vande Walle, L.; Jimenez Fernandez, D.; Demon, D.; Van Laethem, N.; Van Hauwermeiren, F.; Van Gorp, H.; Van Opdenbosch, N.; Kayagaki, N.; Lamkanfi, M.
Does caspase-12 suppress inflammasome activation? (2016), Nature, 534, E1-E4 .

Search for more literature for 3.4.22.B66

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O08736	-	-

General Information

General Information	Comment	Organism
physiological function	caspase-12 knockout mice also lack caspase-11 expression. Caspase-12 deficiency in both ex vivo-stimulated bone-marrow-derived macrophages and in in vivo-challenged mice fails to increase caspase-1 activation. Release of mature IL-1beta and IL-18 by both the canonical and noncanonical inflammasome pathways is consequently also not enhanced by deletion of caspase-12	Mus musculus

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Release 2023.1 (January 2023)