Information on EC 3.4.22.B66 - caspase-12

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY hide
3.4.22.B66
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
caspase-12
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
carbon tetrachloride-induced apoptosis and liver damage is markedly reduced in caspase-12-deficient mice
physiological function
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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benzene, increase of caspase-12 expression after 12 days of oral benzene treatment to p53KO mice
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
procaspase-12 is predominantly located on the cytoplasmic side of the endoplasmic reticulum
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36000
x * 36000, active enzyme, SDS-PAGE
55000
x * 55000, proenzyme, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 36000, active enzyme, SDS-PAGE; x * 55000, proenzyme, SDS-PAGE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activation of caspase-12 is detected in the liver at 12 and 24 h after carbon tetrachloride treatment
O,O-diethyl-O-4-nitrophenylphosphate up-regulates caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibits O,O-diethyl-O-4-nitrophenylphosphate-induced increase of caspase-12 expression. During the application of 5 nM POX for 0-8 h, caspase-12 expression increases significantly and continuously, and reaches the peak after 8 h treatment. However, caspase-12 expression after treatment with 5 nM POX for 16 h is similar to the control
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