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malfunction
carbon tetrachloride-induced apoptosis and liver damage is markedly reduced in caspase-12-deficient mice
physiological function
-
caspase-12 is an important upstream messenger in POX-induced apoptosis in EL-4 cells
physiological function
-
caspase-12 plays a role in controlling West Nile virus viral infection via the pattern recognition receptor RIG-I. Caspase-12 positively modulates the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I
physiological function
caspase-12 plays a pivotal role in carbon tetrachloride-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via capase-9 activation
physiological function
apoptosis is elevated when myoblasts are subjected to cyclic mechanical stretch for 12, 24, and 36 hr. Cyclic mechanical stretch triggers the endoplasmic reticulum stress and caspase-12 cleavage. Endoplasmic reticulum stress inhibitor GSK 2606414 suppresses the cyclic mechanical stretch-induced cleavage of caspase-12 and myoblast apoptosis. Silencing of caspase-12 attenuates the apoptosis of myoblasts. Cells overexpressing a truncated caspase-12 segment which starts from Asp94 and ends at Asn419, undergo apoptosis under both static and stretched conditions
physiological function
caspase-12 knockout mice also lack caspase-11 expression. Caspase-12 deficiency in both ex vivo-stimulated bone-marrow-derived macrophages and in in vivo-challenged mice fails to increase caspase-1 activation. Release of mature IL-1beta and IL-18 by both the canonical and noncanonical inflammasome pathways is consequently also not enhanced by deletion of caspase-12
physiological function
cyclic stretch leads to apoptosis in myoblast. GRP78 mRNA and protein are significantly increased and ER chaperone CHOP and caspase-12 are activated in myoblast exposed to cyclic stretch. Caspase-12 inhibition reduces stretch-induced apoptosis, and caspase-12 activates caspase-3 to induce apoptosis
physiological function
in mice with experimental autoimmune encephalomyelitis, expression of chaperone CHOP, caspase-12, and protein disulfide isomerase is upregulated in the brain. Elevated levels of caspase-12/CHOP are observed in astrocytes, oligodendrocytes, and microglia in the hippocampus section of experimental autoimmune encephalomyelitis mice
physiological function
loss of caspase-12 in mouse strains predisposes mice to develop obesity, metabolic inflammation, and insulin resistance, whereas loss of caspase-11 has no effect. The Nlrp3 inflammasome pathway mediates the metabolic syndrome of caspase-12 deficient mice
physiological function
-
overexpression of Casp12 mediates IkappaBalpha degradation and significantly increases NFkappaB activity. Exposure of human nasopharyngeal carcinoma cells to phorbol-12-myristate-13-acetate increases the levels of Casp12 and MMP-9 resulting in nasopharyngeal carcinoma cells invasion. Suppression of Casp12 or an inhibitor of Casp12 markedly decreases the level of phorbol-12-myristate-13-acetate-induced MMP-9 protein and cell invasion. Suppression of Casp12 significantly inhibits the basal activity of NFkappaB and decreases the phorbol-12-myristate-13-acetate-induced NFkappaB reporter activity
physiological function
the majority of people lack a functional caspase-12 because of a T125 single nucleotide polymorphis. A fraction of African descendents express full-length caspase-12. The coding T125C single nucleotide polymorphism is not associated with metabolic parameters in humans
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Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
Mus musculus
brenda
Wang, P.; Arjona, A.; Zhang, Y.; Sultana, H.; Dai, J.; Yang, L.; LeBlanc, P.M.; Doiron, K.; Saleh, M.; Fikrig, E.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Nat. Immunol.
11
912-919
2010
Mus musculus
brenda
Li, L.; Cao, Z.; Jia, P.; Wang, Z.
Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells
Toxicol. In Vitro
24
728-736
2010
Mus musculus
brenda
Liu, H.; Wang, Z.; Nowicki, M.J.
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
World J. Gastroenterol.
20
18189-18198
2014
Mus musculus (O08736)
brenda
Ahn, Y.; Kim, M.; Chung, S.
Calpain and caspase-12 expression in lens epithelial cells of diabetic cataracts
Am. J. Ophthalmol.
167
31-37
2016
Homo sapiens
brenda
Zhang, Q.; Liu, J.; Chen, S.; Liu, J.; Liu, L.; Liu, G.; Wang, F.; Jiang, W.; Zhang, C.; Wang, S.; Yuan, X.
Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress
Apoptosis
21
432-442
2016
Rattus norvegicus (Q920D5)
brenda
Kamarehei, M.; Kabudanian Ardestani, S.; Firouzi, M.; Zahednasab, H.; Keyvani, H.; Harirchian, M.H.
Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice
Brain Res. Bull.
147
174-182
2019
Mus musculus (O08736)
brenda
Song, J.; Zhang, Q.; Wang, S.; Yang, F.; Chen, Z.; Dong, Q.; Ji, Q.; Yuan, X.; Ren, D.
Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts
J. Cell. Physiol.
233
9473-9487
2018
Mus musculus (O08736)
brenda
Skeldon, A.M.; Morizot, A.; Douglas, T.; Santoro, N.; Kursawe, R.; Kozlitina, J.; Caprio, S.; Mehal, W.Z.; Saleh, M.
Caspase-12, but not Caspase-11, inhibits obesity and insulin resistance
J. Immunol.
196
437-447
2016
Mus musculus (O08736), Mus musculus, Homo sapiens (Q6UXS9), Homo sapiens
brenda
Vande Walle, L.; Jimenez Fernandez, D.; Demon, D.; Van Laethem, N.; Van Hauwermeiren, F.; Van Gorp, H.; Van Opdenbosch, N.; Kayagaki, N.; Lamkanfi, M.
Does caspase-12 suppress inflammasome activation?
Nature
534
E1-E4
2016
Mus musculus (O08736)
brenda
Chu, W.K.; Hsu, C.C.; Huang, S.F.; Hsu, C.C.; Chow, S.E.
Caspase 12 degrades IkappaBalpha protein and enhances MMP-9 expression in human nasopharyngeal carcinoma cell invasion
Oncotarget
8
33515-33526
2017
Homo sapiens
brenda
3.4.22.B66 caspase-12
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