Literature summary for 3.4.22.B5 extracted from

Casgrain, P.A.; Martel, C.; McMaster, W.R.; Mottram, J.C.; Olivier, M.; Descoteaux, A.
Cysteine peptidase B regulates Leishmania mexicana virulence through the modulation of GP63 expression (2016), PLoS Pathog., 12, e1005658 .

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Organism

Organism	UniProt	Comment	Textmining
Leishmania mexicana	P36400	-	-
Leishmania mexicana M379	P36400	-	-

General Information

General Information	Comment	Organism
physiological function	in a CPB-deficient mutant, both SNARE proteins VAMP3 and VAMP8 are down-modulated in a CPB-dependent manner. Expression of the virulence-associated GPI-anchored metalloprotease GP63 is inhibited in the absence of CPB. Expression of GP63 in the CPB-deficient mutant is sufficient to down-modulate VAMP3 and VAMP8. Episomal expression of GP63 enables the CPB-deficient mutant to establish infection in macrophages	Leishmania mexicana

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Release 2023.1 (January 2023)