Literature summary for 3.4.22.B26 extracted from

Andrique, C.; Morardet, L.; Linares, L.K.; Cisse, M.Y.; Merle, C.; Chibon, F.; Provot, S.; Hay, E.; Ea, H.K.; Cohen-Solal, M.; Modrowski, D.
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence (2018), JCI Insight, 3, 121225 .

Search for more literature for 3.4.22.B26

Application

Application	Comment	Organism
medicine	calpain-6 expression is associated with cancer stem cell features. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux	Homo sapiens
medicine	calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y6Q1	-	-
Mus musculus	O35646	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
143B cell	-	Homo sapiens	-
K7M2-WT cell	-	Mus musculus	-
MDA-MB-231 cell	-	Homo sapiens	-
PC-3 cell	-	Homo sapiens	-
TC-71 cell	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	calpain-6 expression is associated with cancer stem cell features. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux	Homo sapiens
physiological function	calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux	Mus musculus

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Release 2023.1 (January 2023)