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Atherosclerosis
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Bone Resorption
Calpain 6, a target molecule of glucocorticoids, regulates osteoclastic bone resorption via cytoskeletal organization and microtubule acetylation.
calpain 6 deficiency
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
calpain 6 deficiency
Calpain-6 deficiency promotes skeletal muscle development and regeneration.
calpain 6 deficiency
Deficiency of calpain-6 inhibits primary ciliogenesis.
Carcinogenesis
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
Carcinogenesis
CAPN6 in disease: An emerging therapeutic target (Review).
Carcinogenesis
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Carcinogenesis
Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas.
Carcinoma
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Carcinoma, Squamous Cell
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Carcinosarcoma
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Diabetic Nephropathies
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Intellectual Disability
Integrated STS/YAC physical, genetic, and transcript map of human Xq21.3 to q23/q24 (DXS1203-DXS1059).
Leiomyoma
CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway.
Leiomyoma
Differential gene expression in uterine leiomyoma.
Leiomyosarcoma
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Leukemia
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Liver Neoplasms
miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
Muscular Atrophy
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Muscular Dystrophies
CAPN6 in disease: An emerging therapeutic target (Review).
Neoplasm Metastasis
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
Neoplasms
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Neoplasms
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
Neoplasms
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.
Neoplasms
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
Neoplasms
CAPN6 in disease: An emerging therapeutic target (Review).
Neoplasms
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Neoplasms
Increased expression of calpain 6 during the progression of uterine cervical neoplasia: Immunohistochemical analysis.
Neoplasms
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Neoplasms
miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
Neoplasms
The PI3K-Akt pathway regulates calpain 6 expression, proliferation, and apoptosis.
Osteosarcoma
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
Osteosarcoma
CAPN6 in disease: An emerging therapeutic target (Review).
Prion Diseases
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.
Renal Insufficiency, Chronic
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Sarcoma
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.
Sarcoma
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Scrapie
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.
Squamous Cell Carcinoma of Head and Neck
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Uterine Cervical Neoplasms
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
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metabolism
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the enzyme capain-6 is negatively controlled by the proteoglycan syndecan-2, that controls the activity of various cytokines and growth factors and also modulates apoptosis and response to cytotoxic agents in osteosarcoma cell lines. Syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6. Calpain-6 expression in osteosarcoma cells depends on endothelin-1, a mediator of the tumor progression in bone. Syndecan-2 overexpression alters ERK1/2, PI3K/AKT and NFjB pathways that are calpain-6-promoting signals downstream of endothelin-1
malfunction
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inhibition of calpain-6 with shRNA results in decreased proliferation, increased spontaneous apoptosis and increased sensitivity to doxorubicin and also methotrexate in responsive and resistant osteosarcoma cells
malfunction
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knockdown of calpain-6 in NIH-3T3 cells results in Rac1 activation, which promotes cell migration, spreading and lamellipodial protrusion. Upon knockdown of calpain-6, GEF-H1 translocates from microtubules to the lamellipodial region and to interact with Rac1. RhoA activity is decreased upon knockdown of calpain-6
physiological function
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calpain-6 is a microtubule-stabilizing protein that regulates Rac1 activity and cell motility through interaction with the Rho guanine-nucleotide-exchange factor GEF-H1. Calpain-6 is involved in the regulation of the organization of cortical actin and subsequent changes in cell motility and morphology, independent of the proteolytic activity of calpains
physiological function
-
calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma
physiological function
-
calpain-6 is a protective factor that contributes to abnormal cell survival
physiological function
calpain-6 expression is associated with cancer stem cell features. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux
physiological function
calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux
physiological function
inflammatory cytokines induce nonproteolytic calpain-6 (CAPN6), which associates with the essential exon junction complex-loading factor CWC22 in the cytoplasm. This association disturbs the nuclear localization of CWC22, thereby suppressing the splicing of target genes, including those related to Rac1 signaling. CAPN6 deficiency in low density lipoprotein receptor-deficient mice restores CWC22/EJC/Rac1 signaling, reduces pinocytotic deposition of native low density lipoprotein in macrophages, and attenuates macrophage recruitment into the lesions, generating an atheroprotective phenotype in the aorta. In macrophages, the induction of CAPN6 in the atheroma interior limits macrophage movements, resulting in a decline in cell clearance from the lesions. Myeloid CAPN6 contributes to atherogenesis in a murine model of bone marrow transplantation
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medicine
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calpain-6 is a therapeutic target in chemoresistant osteosarcoma
medicine
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calpain-6 is a possible therapeutic target in chemoresistant osteosarcoma
medicine
calpain-6 expression is associated with cancer stem cell features. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux
medicine
calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux
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Tonami, K.; Kurihara, Y.; Aburatani, H.; Uchijima, Y.; Asano, T.; Kurihara, H.
Calpain 6 is involved in microtubule stabilization and cytoskeletal organization
Mol. Cell. Biol.
27
2548-2561
2007
Mus musculus (O35646)
brenda
Marion, A.; Dieudonne, F.X.; Patino-Garcia, A.; Lecanda, F.; Marie, P.J.; Modrowski, D.
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma
Int. J. Cancer
130
2514-2525
2011
Homo sapiens
brenda
Tonami, K.; Kurihara, Y.; Arima, S.; Nishiyama, K.; Uchijima, Y.; Asano, T.; Sorimachi, H.; Kurihara, H.
Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1
J. Cell Sci.
124
1214-1223
2011
Mus musculus
brenda
Miyazaki, T.; Tonami, K.; Hata, S.; Aiuchi, T.; Ohnishi, K.; Lei, X.F.; Kim-Kaneyama, J.R.; Takeya, M.; Itabe, H.; Sorimachi, H.; Kurihara, H.; Miyazaki, A.
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing
J. Clin. Invest.
126
3417-3432
2016
Mus musculus (O35646), Mus musculus
brenda
Andrique, C.; Morardet, L.; Linares, L.K.; Cisse, M.Y.; Merle, C.; Chibon, F.; Provot, S.; Hay, E.; Ea, H.K.; Cohen-Solal, M.; Modrowski, D.
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence
JCI Insight
3
121225
2018
Mus musculus (O35646), Mus musculus, Homo sapiens (Q9Y6Q1)
brenda