Information on EC 3.4.22.B26 - calpain 6

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.22.B26
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
calpain 6
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
A microtubule-stabilizing protein. The enzyme lacks the active-site catalytic cysteine residue and proteolytic activity has not been detected.
show the reaction diagram
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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the enzyme capain-6 is negatively controlled by the proteoglycan syndecan-2, that controls the activity of various cytokines and growth factors and also modulates apoptosis and response to cytotoxic agents in osteosarcoma cell lines. Syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6. Calpain-6 expression in osteosarcoma cells depends on endothelin-1, a mediator of the tumor progression in bone. Syndecan-2 overexpression alters ERK1/2, PI3K/AKT and NFjB pathways that are calpain-6-promoting signals downstream of endothelin-1
physiological function
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
benzyloxycarbonyl-L-leucyl-L-leucinal
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Calpeptin
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Manually annotated by BRENDA team
first mandibular arch
Manually annotated by BRENDA team
downregulated after birth
Manually annotated by BRENDA team
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
calpain-6 expression depends on NFkappaB activity and endothelin-1. Calpain-6 expression is increased by doxorubicin; calpain-6 expression in osteosarcoma cells depends on endothelin-1. Calpain-6 is increased by doxorubicin (10 ng/ml) and expressed at higher levels in doxorubicin-resistant U2OS osteosarcoma-derived cells as compared to responsive cells
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calpain-6 is a target gene downregulated by syndecan-2 in cells and in vivo. Syndecan-2 decreases calpain-6 expression by inhibiting endothelin-1-induced signaling
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calpain-6 mRNA and CAPN6 protein levels are down-regulated by 10% fetal calf serum
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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calpain-6 is a possible therapeutic target in chemoresistant osteosarcoma; calpain-6 is a therapeutic target in chemoresistant osteosarcoma