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Literature summary for 3.4.22.B19 extracted from

  • Sun, J.
    Pathogenic bacterial proteins and their anti-inflammatory effects in the eukaryotic host (2009), Antiinflamm. Antiallergy Agents Med. Chem., 8, 214-227.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IkappaBalpha-ubiquitin + H2O Yersinia sp.
-
 IkappaBalpha + ubiquitin
-
 ?
TRAF2-ubiquitin + H2O Yersinia sp.
-
 TRAF2 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O Yersinia sp.
-
 TRAF6 + ubiquitin
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IkappaBalpha-ubiquitin + H2O
-
 Yersinia sp. IkappaBalpha + ubiquitin
-
 ?
additional information YopH is a tyrosine phosphatase Yersinia sp. ?
-
 ?
additional information YopJ uses acetyl-coenzyme A to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation Yersinia sp. ?
-
 ?
TRAF2-ubiquitin + H2O
-
 Yersinia sp. TRAF2 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O
-
 Yersinia sp. TRAF6 + ubiquitin
-
 ?

Synonyms

Synonyms Comment Organism
Yersinia outer protein
-
 Yersinia sp.
YopJ
-
 Yersinia sp.

General Information

General Information Comment Organism
physiological function YopJ deactivates MAPK- and NF-kappaB signaling pathways, and induces apoptosis of immune cells, YopJ inhibits the c-JNK pathway, attenuates the inflammatory responses, and interferes with the cell apoptotic process. When YopJ is replaced with YopP, the YopP-expressing Yersinia pestis strain exhibits high cytotoxic activity against macrophages Yersinia sp.