Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.B19 extracted from

  • Zhou, H.; Monack, D.M.; Kayagaki, N.; Wertz, I.; Yin, J.; Wolf, B.; Dixit, V.M.
    Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappaB activation (2005), J. Exp. Med., 202, 1327-1332.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B19

Protein Variants

Protein Variants Comment Organism
C172A YopJ mutant C172A is inactive against ubiquitin-7-amido-4-methylcoumarin Yersinia pseudotuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 ubiquitin-7-amido-4-methylcoumarin pH 8.0 Yersinia pseudotuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
TRAF2-ubiquitin + H2O Yersinia pseudotuberculosis YopJ is a promiscuous deubiquitinating enzyme that negatively regulates signaling by removing ubiquitin moieties from proteins, such as TRAF2, TRAF6, and IkappaBalpha. YopJ cleaves both K48- and K63-linked polyubiquitin TRAF2 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O Yersinia pseudotuberculosis YopJ is a promiscuous deubiquitinating enzyme that negatively regulates signaling by removing ubiquitin moieties from proteins, such as TRAF2, TRAF6, and IkappaBalpha. YopJ cleaves both K48- and K63-linked polyubiquitin TRAF6 + ubiquitin
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia pseudotuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
wild-type YopJ and YopJ mutant C172A from insect cells Yersinia pseudotuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no cleavage of (SUMO-1)-7-amido-4-methylcoumarin Yersinia pseudotuberculosis ?
-
 ?
TRAF2-ubiquitin + H2O YopJ is a promiscuous deubiquitinating enzyme that negatively regulates signaling by removing ubiquitin moieties from proteins, such as TRAF2, TRAF6, and IkappaBalpha. YopJ cleaves both K48- and K63-linked polyubiquitin Yersinia pseudotuberculosis TRAF2 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O YopJ is a promiscuous deubiquitinating enzyme that negatively regulates signaling by removing ubiquitin moieties from proteins, such as TRAF2, TRAF6, and IkappaBalpha. YopJ cleaves both K48- and K63-linked polyubiquitin Yersinia pseudotuberculosis TRAF6 + ubiquitin
-
 ?
ubiquitin-7-amido-4-methylcoumarin + H2O
-
 Yersinia pseudotuberculosis ubiquitin + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
YopJ
-
 Yersinia pseudotuberculosis