Cloned (Comment) | Organism |
---|---|
His-tagged artificial polyprotein (cyan fluorescent protein-SARS-CoV 3CLpro-yellow fluorescent protein) expressed in Escherichia coli | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-naphthylmethyl)isatin-5-carboxamide | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Thr-Ser-Ala-Val-Leu-Gln-p-nitroanilide + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Thr-Ser-Ala-Val-Leu-Gln + p-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | tendency of substrate induced dimer formation, gel filtration, analytic ultracentrifugation | Severe acute respiratory syndrome-related coronavirus |
Synonyms | Comment | Organism |
---|---|---|
SARS coronavirus 3C-like proteinase | - |
Severe acute respiratory syndrome-related coronavirus |
SARS-3CLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00037 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 1-(2-naphthylmethyl)isatin-5-carboxamide |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
Thr-Ser-Ala-Val-Leu-Gln-p-nitroanilide | His-tagged artificial polyprotein (cyan fluorescent protein-SARS-CoV 3CLpro-yellow fluorescent protein) | Severe acute respiratory syndrome-related coronavirus | |
0.11 | - |
Thr-Ser-Ala-Val-Leu-Gln-p-nitroanilide | His-tagged artificial polyprotein (SARS-CoV 3CLpro-yellow fluorescent protein) | Severe acute respiratory syndrome-related coronavirus | |
0.53 | - |
Thr-Ser-Ala-Val-Leu-Gln-p-nitroanilide | SARS-CoV 3CLpro | Severe acute respiratory syndrome-related coronavirus |