Application | Comment | Organism |
---|---|---|
medicine | this enzyme is a target for the design of potential anti-SARS drugs | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2-difluoro-2-(pyridin-3-yl)-1-(thiophen-2-yl)ethanone | 0.1 mM, 38% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-(3-chlorophenyl)-2,2-difluoro-1-(furan-2-yl)ethanone | 0.1 mM, 13% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-(3-chlorophenyl)-2-fluoro-1-(furan-2-yl)ethanone | 0.1 mM, 15% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2-fluoroethanone | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(5-bromopyridin-3-yl)-2,2-difluoro-1-(furan-2-yl)ethanone | 0.1 mM, 21% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-(5-chloropyridin-3-yl)-2,2-difluoro-1-(furan-2-yl)ethanone | 0.1 mM, 27% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-(5-chloropyridin-3-yl)-2-fluoro-1-(furan-2-yl)ethanone | 0.1 mM, 14% inhibition | Severe acute respiratory syndrome-related coronavirus | |
2-fluoro-2-(pyridin-3-yl)-1-(thiophen-2-yl)ethanone | 0.1 mM, 10% inhibition | Severe acute respiratory syndrome-related coronavirus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coronavirus polyprotein + H2O | Severe acute respiratory syndrome-related coronavirus | 3CLpro processes the translated polyproteins to functional viral proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-SVTLQSG-Tyr(NO2)Arg + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
coronavirus polyprotein + H2O | 3CLpro processes the translated polyproteins to functional viral proteins | Severe acute respiratory syndrome-related coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.013 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone | |
0.028 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2-fluoroethanone | |
0.057 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2,2-difluoroethanone | |
0.075 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-(5-bromopyridin-3-yl)-1-(2-(4-chlorophenyl)oxazol-5-yl)ethanone |