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Literature summary for 3.4.21.B21 extracted from

  • Miller, D.P.; McDowell, J.V.; Bell, J.K.; Goetting-Minesky, M.P.; Fenno, J.C.; Marconi, R.T.
    Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease (2014), Mol. Oral Microbiol., 29, 194-207.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein factor H + H2O Treponema denticola
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Treponema denticola
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 diverse strains, i.e. 35405, MS25, 33520, N17A1, GM-1, SP48, SP55, SP54, SP50, SP49, SP72, 35404, SP64, 33521, CF171, and CF170
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity of diverse strains with cell-bound substrate protein factor H, overview Treponema denticola

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-4-nitroanilide + H2O
-
 Treponema denticola N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + 4-nitroaniline
-
 ?
protein factor H + H2O
-
 Treponema denticola ?
-
 ?

Synonyms

Synonyms Comment Organism
dentilisin
-
 Treponema denticola

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Treponema denticola

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Treponema denticola

General Information

General Information Comment Organism
physiological function negative complement regulatory protein factor H bound to the FhbB protein on the surface of Treponema denticola cell curface to avoid complement-mediated cell killing. The enzyme activity triggers localized dysregulation of complement activation in periodontal pockets Treponema denticola