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Literature summary for 3.4.21.91 extracted from

  • Yin, Z.; Patel, S.J.; Wang, W.; Chan, W.; Ranga Rao, K.R.; Wang, G.; Ngew, X.; Patel, V.; Beer, D.; Knox, J.E.; Ma, N.L.; Ehrhardt, C.; Lim, S.P.; Vasudevan, S.G.; Keller, T.H.
    Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors (2006), Bioorg. Med. Chem. Lett., 16, 40-43.
    View publication on PubMed
Search for more literature for 3.4.21.91

Inhibitors

Inhibitors Comment Organism Structure
Bz-Ala-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Arg-Arg-H
-
 Dengue virus
Bz-D-Nle-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Lys-Arg-Arg-H
-
 Dengue virus
Bz-N-Me-Nle-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Ala-Arg-Arg-H
-
 Dengue virus
Bz-Nle-D-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Ala-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Arg-(p-Cl)Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-(p-CN)Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-(p-guanidinyl)Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-(p-Me)Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-(p-Ph)Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Ala-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Arg-D-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Arg-homoPhe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Lys-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Phe-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Phg-H
-
 Dengue virus
Bz-Nle-Lys-Arg-Trp-H
-
 Dengue virus
Bz-Nle-Lys-D-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Lys-Arg-H
-
 Dengue virus
Bz-Nle-Lys-N-Me-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Phe-Arg-H
-
 Dengue virus
Bz-Nle-Lys-Pro-Arg-H
-
 Dengue virus
Bz-Nle-N-Me-Lys-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Phe-Arg-Arg-H
-
 Dengue virus
Bz-Nle-Pro-Arg-Arg-H
-
 Dengue virus
Bz-Phe-Lys-Arg-Arg-H
-
 Dengue virus
additional information P2 Arg residue is more important for enzyme interactions than P1 Arg. Tri- and dipeptide aldehyde inhibitors afford low micromolar activity Dengue virus

Organism

Organism UniProt Comment Textmining
Dengue virus
-
-
-

Synonyms

Synonyms Comment Organism
NS3 protease
-
 Dengue virus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
 Bz-Lys-Arg-Arg-H
-
 Dengue virus
0.0028
-
 Bz-Nle-Lys-Arg-(p-guanidinyl)Phe-H
-
 Dengue virus
0.0053
-
 Bz-Ala-Lys-Arg-Arg-H
-
 Dengue virus
0.0058
-
 Bz-Nle-Lys-Arg-Arg-H
-
 Dengue virus
0.006
-
 Bz-Nle-Lys-Arg-(p-Me)Phe-H
-
 Dengue virus
0.0068
-
 Bz-Phe-Lys-Arg-Arg-H
-
 Dengue virus
0.0075
-
 Bz-Nle-Lys-Arg-Trp-H
-
 Dengue virus
0.0094
-
 Bz-D-Nle-Lys-Arg-Arg-H
-
 Dengue virus
0.0116
-
 Bz-Nle-Lys-Arg-(p-Ph)Phe-H
-
 Dengue virus
0.012
-
 Bz-Arg-Arg-H
-
 Dengue virus
0.0158
-
 Bz-Nle-Phe-Arg-Arg-H
-
 Dengue virus
0.0159
-
 Bz-Nle-Lys-Arg-Phe-H
-
 Dengue virus
0.0186
-
 Bz-Nle-Lys-Arg-(p-CN)Phe-H
-
 Dengue virus
0.0205
-
 Bz-Nle-Lys-Arg-Lys-H
-
 Dengue virus
0.0221
-
 Bz-Nle-Ala-Arg-Arg-H
-
 Dengue virus
0.0286
-
 Bz-Nle-D-Lys-Arg-Arg-H
-
 Dengue virus
0.033
-
 Bz-Nle-Lys-Arg-Phg-H
-
 Dengue virus
0.0407
-
 Bz-Nle-Lys-Phe-Arg-H
-
 Dengue virus
0.0413
-
 Bz-Nle-Lys-Lys-Arg-H
-
 Dengue virus
0.0437
-
 Bz-N-Me-Nle-Lys-Arg-Arg-H
-
 Dengue virus
0.0474
-
 Bz-Nle-Lys-N-Me-Arg-Arg-H
-
 Dengue virus
0.051
-
 Bz-Nle-Lys-Arg-D-Arg-H
-
 Dengue virus
0.0614
-
 Bz-Nle-Pro-Arg-Arg-H
-
 Dengue virus
0.109
-
 Bz-Nle-Lys-Pro-Arg-H
-
 Dengue virus
0.1133
-
 Bz-Nle-N-Me-Lys-Arg-Arg-H
-
 Dengue virus
0.115
-
 Bz-Nle-Lys-D-Arg-Arg-H
-
 Dengue virus
0.138
-
 Bz-Nle-Lys-Arg-(p-Cl)Phe-H
-
 Dengue virus
0.193
-
 Bz-Nle-Lys-Arg-Ala-H
-
 Dengue virus
0.5
-
 Bz-Nle-Lys-Ala-Arg-H
-
 Dengue virus
0.5
-
 Bz-Nle-Lys-Arg-homoPhe-H
-
 Dengue virus