Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Mus musculus | - |
angiotensin II + His-Leu | - |
? | |
Fibronectin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P21812 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Mus musculus | angiotensin II + His-Leu | - |
? | |
Fibronectin + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mast cell protease 4 | - |
Mus musculus |
MCP4 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | ,ice deficient in mouse mast cell protease 4 (MCP4) have increased obstruction-induced fibrosis when compared to wild type mice. Kidneys of MCP4-deficient mice have higher levels of renal tubular damage, interstitial fibrosis, collagen deposition, increased a-smooth muscle actin, and decreased E-cadherin expression compared to the kidneys of wild type mice | Mus musculus |
physiological function | mast cell released mast cell protease 4 has anti-fibrotic potential in acutely induced obstructive nephropathy | Mus musculus |