Information on EC 3.4.21.39 - chymase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.21.39
-
RECOMMENDED NAME
GeneOntology No.
chymase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/-
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
CAS REGISTRY NUMBER
COMMENTARY hide
97501-92-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
chymases with Val199 are found only in animals expressing multiple chymases, consistent with the premise that their substrate specificity differs from that of chymases with Gly199
-
-
Manually annotated by BRENDA team
short-tailed opossum
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
a 6-h treatment with 60 ng/ml chymase has a maximum effect on the stimulation of transforming growth factor-beta1 expression. In addition, a 6-h treatment with 30 ng/ml chymase has a maximum effect on the stimulation of interleukin-1beta expression
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Abz-GIAPFCDLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFCDLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFCMLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFCPLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFCRLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFDMLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFRMLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFSMLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIATFWMLMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-GIEPFSDPMPEQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-TPFSALQ-EDDnp + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-TPWSALQ-YNO2 + H2O
?
show the reaction diagram
-
-
-
-
?
acetyltyrosine ethyl ester + H2O
acetyl-Tyr + ethanol
show the reaction diagram
-
-
-
-
?
Ala-Ala-Pro-Leu-4-nitroanilide + H2O
Ala-Ala-Pro-Leu + 4-nitroaniline
show the reaction diagram
Ala-Ala-Pro-Met-4-nitroanilide + H2O
Ala-Ala-Pro-Met + 4-nitroaniline
show the reaction diagram
Ala-Ala-Pro-Phe-4-nitroanilide + H2O
Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
angiotensin I + H2O
angiotensin II + ?
show the reaction diagram
angiotensin I + H2O
angiotensin II + His-Leu
show the reaction diagram
angiotensin I + H2O
His-[2-amino-4-(2,3-dinitrophenylamino)-butyrate] + DRVYIHPF
show the reaction diagram
-
the enzyme cleaves between Phe and His of modified angiotensin I permitting the release of His-[2-amino-4-(2,3-dinitrophenylamino)-butyrate]
-
-
?
Angiotensin II + H2O
?
show the reaction diagram
-
-
-
-
?
angotensin I + H2O
angiotensin II
show the reaction diagram
-
-
-
-
?
apo-ornithine-aminotransferase + H2O
?
show the reaction diagram
-
-
-
-
?
atrial natriuretic peptide clearance receptor + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
benzoyl-Arg-4-methylcoumarin 7-amide + H2O
benzoyl-Arg + 4-methylcoumarin 7-amide
show the reaction diagram
-
1.2% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
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-
?
benzoyl-Arg-4-nitroanilide + H2O
benzoyl-Arg + 4-nitroanilide
show the reaction diagram
-
no activity with enzyme forms 1D and 1E
-
-
?
benzoyl-L-Tyr-4-nitroanilide + H2O
benzoyl-L-Tyr + 4-nitroaniline
show the reaction diagram
-
activity with enzyme form 1A, no activity with enzyme form 1B, 1C, 1D, 1E
-
-
?
benzyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Ala + 4-nitrophenyl
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Arg-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Arg + 4-nitrophenol
show the reaction diagram
-
no activity with enzyme form 1B, 1C and 1E
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-
?
benzyloxycarbonyl-D-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl + D-Ala-4-nitrophenol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Phe-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Phe + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Trp-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Trp + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Tyr-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Tyr-4-nitrophenyl ester
show the reaction diagram
-
no activity with enzyme form 1C and 1E
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-
?
Big endothelin-1 + H2O
?
show the reaction diagram
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
Big-endothelin-1 + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
-
-
-
-
?
biglycan + H2O
?
show the reaction diagram
CAAPFW + H2O
?
show the reaction diagram
-
-
-
-
?
cadherin-10 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
cadherin-13 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
chemerin + H2O
?
show the reaction diagram
-
mast cell chymase abolishes chemerin activity by the removal of additional amino acids from its C-terminus, this effect is specific to bioactive chemerin (chemerin-157 and to a lesser extent chemerin-156)
-
-
?
cholesteryl ester transfer protein + H2O
?
show the reaction diagram
-
-
-
-
?
cholesteryl ester transfer protein-high density lipoprotein complex + H2O
?
show the reaction diagram
-
-
-
-
?
collagen alpha-1(VI) chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
collagen alpha-1(XII) chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
connective tissue-activating peptide III + H2O
neutrophil-activating peptide 2 + precursorpeptide
show the reaction diagram
-
i.e. CTAP-II
i.e. NAP-2
-
?
desmocollin-3 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
DRVWIHPFHL + H2O
?
show the reaction diagram
-
-
-
-
?
DRVWIHPLHL + H2O
?
show the reaction diagram
-
-
-
-
?
DRVWIHPWHL + H2O
?
show the reaction diagram
-
-
-
-
?
endothelin-1 + H2O
31 amino-acid fragment of ET-1 + ?
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
H2N(CH2)5CO-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 70 + H2O
?
show the reaction diagram
helodermin + H2O
?
show the reaction diagram
-
-
-
-
?
HMGB1 + H2O
?
show the reaction diagram
integrin alpha-11 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
integrin alpha-3 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
integrin alpha-7 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
interleukin 1beta precursor + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-18 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-1beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-33 + H2O
?
show the reaction diagram
laminin alpha-3 chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
laminin alpha-4 chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
laminin alpha-5 chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
laminin gamma-1 chain + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
latent transforming growth factor-beta + H2O
active transforming growth factor-beta + ?
show the reaction diagram
matrix metalloprotease 8 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
MeO-succinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
MeO-succinyl-Ala-Ala-Pro-Val + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
methoxy-succinyl-Ala-Ala-Pro-Met-p-nitroanilide + H2O
methoxy-succinyl-Ala-Ala-Pro-Met + p-nitroaniline
show the reaction diagram
-
low cleavage efficiency
-
-
-
methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline
show the reaction diagram
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
show the reaction diagram
methoxysuccinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
methoxysuccinyl-Arg-Ala-Tyr-4-nitroanilide + H2O
methoxysuccinyl-Arg-Ala-Tyr + 4-nitroaniline
show the reaction diagram
MR121-CAAPFW + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-Try ethyl ester + H2O
N-benzoyl-L-Try + ethanol
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-Try ethyl ester + H2O
N-benzoyl-L-Tyr + ethanol
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-tyrosine ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline
show the reaction diagram
-
-
-
-
-
N-succinyl-Ala-His-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-His-Pro-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-p-nitroanilide + H2O
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
show the reaction diagram
neurotensin + H2O
?
show the reaction diagram
-
-
-
-
?
plasmin + H2O
?
show the reaction diagram
pro-collagen + H2O
collagen + ?
show the reaction diagram
-
-
-
-
?
pro-interleukin-18 + H2O
interleukin-18 fragments
show the reaction diagram
-
cleaves recombinant pro-interleukin-18 at 56-Phe
16 and 20 kDa fragments, the 16 kDa fragment is biologically active
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 2 + H2O
matrix metalloprotease 2 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
show the reaction diagram
-
-
-
-
?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
4.6% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
pro-transforming growth factor-beta + H2O
transforming growth factor-beta + ?
show the reaction diagram
-
-
-
-
?
pro-transforming growth factor-beta1 + H2O
transforming growth factor-beta1 + ?
show the reaction diagram
-
-
-
-
?
proangiotensin-12 + H2O
angiotensin II
show the reaction diagram
-
-
-
-
?
procollagen + H2O
collagen + ?
show the reaction diagram
-
-
-
-
?
promatrix metalloproteinase 9 + H2O
matrix metalloproteinase 9
show the reaction diagram
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
show the reaction diagram
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
show the reaction diagram
protocadherin alpha-4 + H2O
?
show the reaction diagram
-
potential substrate
-
-
?
secretory leucocyte protease inhibitor + H2O
?
show the reaction diagram
-
cleaved secretory leucocyte protease inhibitor is a biomarker of chymase activity
-
-
?
secretory leukocyte protease inhibitor + H2O
?
show the reaction diagram
-
the cleavage of recombinant human secretory leukocyte protease inhibitor by human chymase occurres at Leu72-Met73
the cleaved form of SLPI can be used as a biomarker of chymase activity
-
?
succinyl-AAPF-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
succinyl-Ala-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Ala-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Gln-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Glu-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Glu-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Gly-Gly-Phe-p-nitroanilide + H2O
succinyl-Gly-Gly-Phe + p-nitroaniline
show the reaction diagram
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-4-nitroanilide + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
succinyl-Leu-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Leu-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Lys-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Lys-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Met-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Met-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-4-nitroanilide + H2O
succinyl-Phe + 4-nitroaniline
show the reaction diagram
-
no activity with enzyme form 1C and 1D
-
-
?
succinyl-Phe-Ala-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Gln-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Glu-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Leu-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Leu-Phe-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Phe-Lys-Phe-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Phe-Met-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Pro-Thr-Phe-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Phe-Thr-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Val-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Phe-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Ser-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Thr-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Val-Pro-Leu-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Val-Pro-Met-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Val-Pro-Phe-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Val-Pro-Pro-Phe-SCH2C6H5 + H2O
?
show the reaction diagram
succinyl-Val-Pro-Trp-4-nitroanilide + H2O
?
show the reaction diagram
succinyl-Val-Pro-Tyr-4-nitroanilide + H2O
?
show the reaction diagram
t-butyloxycarbonyl-Ala-Ala-Asp-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Leu-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Met-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Phe-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
t-butyloxycarbonyl-Ala-Ala-Ser-thiobenzyl ester + H2O
?
show the reaction diagram
-
weak activity
-
-
?
t-butyloxycarbonyl-Ala-Ala-Trp-thiobenzyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
t-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
2.6% of the activity with succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin 7-amide
-
-
?
thrombin + H2O
?
show the reaction diagram
tissue necrosis factor + H2O
?
show the reaction diagram
-
-
-
?
transforming growth factor beta-binding protein + H2O
transforming growth factor beta + protein
show the reaction diagram
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
show the reaction diagram
-
-
-
-
?
vasoactive intestinal polypeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Vitronectin + H2O
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
angiotensin I + H2O
angiotensin II + ?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
show the reaction diagram
angotensin I + H2O
angiotensin II
show the reaction diagram
-
-
-
-
?
Big endothelin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
Big-endothelin-1 + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
-
-
-
-
?
biglycan + H2O
?
show the reaction diagram
endothelin-1 + H2O
31 amino-acid fragment of ET-1 + ?
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
heat shock protein 70 + H2O
?
show the reaction diagram
HMGB1 + H2O
?
show the reaction diagram
interleukin-18 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-1beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-33 + H2O
?
show the reaction diagram
plasmin + H2O
?
show the reaction diagram
pro-collagen + H2O
collagen + ?
show the reaction diagram
-
-
-
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 2 + H2O
matrix metalloprotease 2 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
show the reaction diagram
-
-
-
-
?
pro-transforming growth factor-beta + H2O
transforming growth factor-beta + ?
show the reaction diagram
-
-
-
-
?
pro-transforming growth factor-beta1 + H2O
transforming growth factor-beta1 + ?
show the reaction diagram
-
-
-
-
?
procollagen + H2O
collagen + ?
show the reaction diagram
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
show the reaction diagram
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
show the reaction diagram
thrombin + H2O
?
show the reaction diagram
tissue necrosis factor + H2O
?
show the reaction diagram
P21812
-
-
-
?
transforming growth factor beta-binding protein + H2O
transforming growth factor beta + protein
show the reaction diagram
-
-
-
-
?
Vitronectin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(6E)-4-[(4-chlorophenyl)sulfonyl]-6-(phenylmethylidene)-1,4-diazepane-2,5-dione
-
-
(6R)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
(6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
potent inhibitor
1-(2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (1-benzyl-3,3,3-trifluoro-2-oxo-propyl)-amide
-
-
1-[(5-fluoro-1-benzothiophen-3-yl)methyl]-3-{[(methoxycarbonyl)(methyl)amino]methyl}-1H-indole-2-carboxylate
-
-
2-(2-[2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
i.e. Y40079, novel, potent and orally active chymase inhibitor which would be a useful tool in elucidating the pathophysiological roles of chymase
2-(2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(3-amino-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid diethylamide
-
-
2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethyl ester
-
-
2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-5-carboxylic acid ethylamide
-
-
2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazol-6-carboxylic acid methyl ester
-
-
2-(2-{2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester
-
-
2-(5-Acetylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Amino-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)acetamide
-
-
2-(5-Amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(2-phenethyl)acetamide
-
-
2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-methylacetamide
-
-
2-(5-Benzenesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Benzoylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
2-(5-Hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Mehoxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Methanesulfonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(5-Oxaloamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-(benzylamino)-4H-3,1-benzoxazin-4-one
-
-
2-(benzyloxycarbonyl-NH(CH2)2CONH)C6H4SO2F
2-(benzyloxycarbonyl-NH(CH2)5CONH)C6H4SO2F
2-(benzyloxycarbonyl-NHCH2CONH)C6H4SO2F
2-(N-benzyl-N-methylamino)-4H-3,1-benzoxazin-4-one
-
inhibitor forms a stable acyl-enzyme with half-life of 53 min
2-(N-benzyl-N-methylamino)-6-methyl-4H-3,1-benzoxazin-4-one
-
-
2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
inhibitor forms a stable acyl-enzyme with half-life of 25 min
2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
2-[2-(4-Fluorophenyl)-5-hydroxysuccinylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[2-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-(5-amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-(5-amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
2-[2-[2-[5-amino-2-(3-nitro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid diethylamide
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-5-carboxylic acid ethylamide
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazol-6-carboxylic acid methyl ester
-
-
2-[2-[2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamido]-3-phenyl-propionyl]-benzooxazole-5-carboxylic acid methyl ester
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid
-
TY-51469, specific chymase inhibitor
2-[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]-N-methylacetamide
-
-
2-[5-Amino-2-(3-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(3-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-aminophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxazolo[4,5-b]pyridin-2-yl-2-oxo-ethyl)-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(2-benzothiazol-2-yl-1-benzyl-2-oxo-ethyl)-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(4,5-dihydro-oxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-fluoro-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-(5-methoxy-benzooxazol-2-yl)-2-oxo-ethyl]-acetamide
-
-
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-benzyl-2-oxo-2-(5-phenyl-benzooxazol-2-yl)-ethyl]-acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(2-benzoxazolyl)carbonyl]-2-phenylethyl]-acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-aminobenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
2-[5-Amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-hydroxybenzoxazol-2-yl)carbonyl]-2-phenylethyl]acetamide
-
-
2-[5-Amino-2-(4-hydroxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-methoxyphenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-2-(4-nitrophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-6-oxo-2-(2-thienyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-6-oxo-2-(3-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-6-oxo-2-(4-pyridyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-[5-Amino-6-oxo-2-(p-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
2-{1-[(1,4-dimethyl-1H-indol-3-yl)methyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}hexanoic acid
-
-
2-{2-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
-
-
2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
-
-
2-{2-[2-(5-Amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
-
novel, potent, and orally active inhibitor. Rapidly after oral administration and has satisfactory bioavailability
2-{2-[2-(5-Amino-6-oxo-2-pyridin-4-yl-6H-pyrimidin-1-yl)-acetylamino]-3-phenyl-propionyl}-benzooxazole-5-carboxylic acid methyl ester
-
-
3,4-dichloroisocoumarin
3-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)-4-methoxybenzonitrile
-
-
3-C6H5CONHC6H4SO2F
3-CF3C6H4SO2F
3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
3-[(3,4-dimethoxyphenyl)sulfonyl]-1-(3,4-dimethylphenyl)imidazoline-2,4-dione
3-[(3-amino-4-carboxy)phenylsulfonyl]-7-chloroquinazorine
3-[5-Amino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)propanamide
-
-
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
4-({1-[(4-methyl-1-benzothiophen-3-yl)methyl]-1H-benzimidazol-2-yl}sulfanyl)butanoic acid
-
-
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
-
-
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
-
4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(2,5-dimethoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(2-ethoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(2-fluorobenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(2-methoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(4,5-dichloro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(5-chloro-2-propoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(5-fluoro-2-methoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(5-hydroxy-2-methoxybenzyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(cyclohexylmethyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(naphthalen-2-ylmethyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione
-
-
4-[(4-chlorophenyl)sulfonyl]-6-(pyridin-4-ylmethyl)-1,4-diazepane-2,5-dione
-
-
4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
4-[1-[[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid
5-fluoresceinylthiocarbamoyl-Ala-Ala-Met phosphonate diphenyl ester
-
-
-
5-hydroxytryptamine
-
-
5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
-
-
6-(2-butoxy-5-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(2-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(3-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(4-chlorobenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(5-chloro-2-ethoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
-
-
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylethyl)-1,4-diazepane-1-carboxamide
-
-
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylpropyl)-1,4-diazepane-1-carboxamide
-
-
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(2-phenylethyl)-1,4-diazepane-1-carboxamide
-
-
6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylpropyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
6-(5-chloro-2-methoxybenzyl)-N-(diphenylmethyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
6-benzyl-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione
-
-
6-methyl-2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
-
acetyl-Ala-Gly-Phe-CH2Cl
-
alpha1-Antichymotrypsin
-
Alpha1-antitrypsin
-
Alpha1-proteinase inhibitor
-
antichymotrypsin
-
-
-
antileukoprotease
-
HUSI-I
-
antipain
antitrypsin
-
-
-
Aprotinin
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
-
-
benzyloxycarbonyl-Ile-Glu-Pro-Phe-COOCH3
-
-
benzyloxycarbonyl-Leu-Phe-chloromethyl ketone
bestatin
-
-
biotinyl-6-aminocaproyl-6-aminocaproyl-Phe-Leu-Phe-phosphonate phenyl ester
-
-
-
C6H5CH2SO3F
-
chymostatin
decanoyl lysophosphatidic acid
-
-
diisopropyl fluorophosphate
dilauroyl phosphatidic acid
-
-
dioleoyl phosphatidic acid
-
-
dipalmitoyl phosphatidic acid
-
-
dipyridyl
-
IC50: above 0.4 mM
distearoyl phosphatidic acid
-
-
Eglin c
elaidic acid
-
-
fatty acids
-
carbon chain length of 14-22
JNJ-10311795
L-1-tosylamide-2-phenyl-ethylchloromethyl ketone
-
-
L-Valyl-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-L-prolinamide hydrochloride
-
-
linoleic acid
-
-
linolenic acid
-
-
lisinopril
-
IC50: above 0.4 mM
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
-
-
methyl[1-naphthalen-2-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphinic acid
-
-
N-(1-Benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide
-
-
N-benzyl-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
N-benzyl-6-(5-chloro-2-methoxybenzyl)-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
-
-
N-substituted saccharin derivatives
-
N-tosyl-L-phenylalanyl-chloromethyl ketone
N-[2-[5-amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetyl]-N,N'-dibenzyl-2,2-difluoro-malonamide
NK-3201
-
-
NK3201
oleamide
-
-
oleic acid
oleoyl lysophosphatidic acid
-
-
ONO-WH-236
40 and 80 mg/kg used experimentally, potent and selective inhibition of chymase activity
-
palmitoyl lysophosphatidic acid
-
-
phenylmethylsulfonyl fluoride
phosphatidic acid
-
from bovine brain
phosphatidylethanolamine
-
-
phosphatidylinositol
-
-
phosphatidylserine
platelet factor 4
-
i.e. PF-4, competitive inhibition of enzyme and cathepsin G
-
RO5066852
-
-
RWJ-355871
SD906
-
-
secretory leucocyte protease inhibitor
-
-
-
secretory leukocyte protease inhibitor
-
-
-
SF-8257
-
-
-
SF2809-I
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0073 mM
SF2809-II
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000041 mM
SF2809-III
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0021 mM
SF2809-IV
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000081
SF2809-V
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000043 mM
SF2809-VI
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000014 mM
soybean tryosin inhibitor
-
-
Soybean trypsin inhibitor
-
stearic acid
substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives
-
-
-
Suc-Val-Pro-PheP-(OPh)2
succinyl-Phe-Leu-Phe-phosphonate diphenyl ester
-
-
-
succinyl-Pro-Leu-Phe-CH2Cl
-
succinyl-Val-Pro-PheP(OPh)2
succinyl-Val-Pro-PheP-(OPh)2
SUN C8077
-
-
-
SUN C8257
-
-
SUN-C8007
SUN-C8257
SUN13350
-
-
-
SUNC8257
-
-
suramin
t-butyloxycarbonyl-Gly-Leu-Phe
tosyl-Phe-CH2Cl
-
-
Trypstatin
-
partial
-
TY-51184
TY-51469
Y-40018
Y-40079
Z-Ile-Glu-Pro-Phe-CO2Me
[1-(1-benzofuran-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(2,3-dihydro-1H-benzotriazol-1-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
less than 50% inhibition at 0.01 mM
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl](2-phenylethyl)phosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]ethylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phenylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-oxo-2-[[(E)-2-phenylethenyl]amino]ethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]ethylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chloro-5-fluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(3-chlorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[(E)-2-(4-methoxyphenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-benzothiophen-3-yl)-2-[[2-(3,4-difluorophenyl)ethyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonate
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(3,4-difluorophenyl)ethenyl]amino]-2-oxoethyl]methylphosphinic acid
-
-
[1-(5-chloro-1-methyl-1H-indol-3-yl)-2-[[(E)-2-(4-fluorophenyl)ethenyl]amino]-2-oxoethyl]phosphonic acid
-
-
[1-naphthalen-1-yl-2-(naphthalen-2-ylamino)-2-oxoethyl]phosphonic acid
-
-
[1-[(1-Benzyl-2-hydroxy-2-oxazolo[5,4-b]pyridin-2-yl-ethylcarbamoyl)-methyl]-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester
-
-
[2-(3-[methyl[1-(naphthalen-2-ylcarbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl)-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
-
-
[4-chloro-2-([1-[(4-chlorophenyl)sulfonyl]-3,7-dioxo-1,4-diazepan-6-yl]methyl)phenoxy]acetic acid
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphatidylcholine
-
activates
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.02 - 1.55
Ala-Ala-Pro-Leu-4-nitroanilide
0.97 - 27
Ala-Ala-Pro-Met-4-nitroanilide
0.47 - 0.65
Ala-Ala-Pro-Phe-4-nitroanilide
0.0223 - 0.398
angiotensin I
0.85
angiotensin II
-
-
0.0141
big endothelin
-
deglycosylated enzyme
-
0.0145
Big endothelin-1
-
glycosylated enzyme
0.31
DRVWIHOLHL
-
-
-
0.06
DRVWIHPFHL
-
-
0.11
DRVWIHPWHL
-
-
1.2
H2N(CH2)5CO-Ala-Ala-Pro-Phe-4-nitroanilide
-
-
0.42
methoxysuccinyl-Ala-Ala-Pro-Phe-4-nitroanilide
-
-
0.3 - 1.8
methoxysuccinyl-Arg-Pro-Tyr-4-nitroanilide
1.56
N-benzoyl-L-Try ethyl ester
-
-
3
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide
-
-
2.6
succinyl-Ala-Ala-Pro-Met-4-nitroanilide
-
-
0.663 - 0.991
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide
0.67 - 0.84
succinyl-Ala-Pro-Phe-4-nitroanilide
0.062
succinyl-Ala-Val-Pro-Phe-4-nitroanilide
-
-
2.7
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide
-
-
-
1 - 2.3
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide
-
0.46 - 0.88
succinyl-Gln-Pro-Phe-4-nitroanilide
0.14 - 0.32
succinyl-Glu-Pro-Phe-4-nitroanilide
0.36 - 0.9
succinyl-Glu-Val-Pro-Phe-4-nitroanilide
0.514 - 0.935
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-4-nitroanilide
0.0157 - 0.0355
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-thiobenzyl ester
0.31 - 0.82
succinyl-Leu-Pro-Phe-4-nitroanilide
0.13 - 0.15
succinyl-Leu-Val-Pro-Phe-4-nitroanilide
0.65 - 4
succinyl-Lys-Pro-Phe-4-nitroanilide
0.078 - 1.5
succinyl-Lys-Val-Pro-Phe-4-nitroanilide
0.11 - 0.44
succinyl-Met-Pro-Phe-4-nitroanilide
0.055 - 0.063
succinyl-Met-Val-Pro-Phe-4-nitroanilide
0.24 - 0.7
succinyl-Phe-Ala-Phe-4-nitroanilide
0.2
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide
-
-
-
0.21 - 0.83
succinyl-Phe-Gln-Phe-4-nitroanilide
0.072 - 1.4
succinyl-Phe-Glu-Phe-4-nitroanilide
0.023 - 0.091
succinyl-Phe-Leu-Phe-4-nitroanilide
0.2
succinyl-Phe-Lys-Phe-4-nitroanilide
-
-
0.22 - 0.29
succinyl-Phe-Met-Phe-4-nitroanilide
0.053 - 0.29
succinyl-Phe-Pro-Phe-4-nitroanilide
0.15
succinyl-Phe-Pro-Thr-Phe-4-nitroanilide
-
-
0.36 - 0.49
succinyl-Phe-Ser-Phe-4-nitroanilide
0.14 - 0.44
succinyl-Phe-Thr-Phe-4-nitroanilide
0.071 - 0.15
succinyl-Phe-Val-Phe-4-nitroanilide
0.056 - 0.17
succinyl-Phe-Val-Pro-Phe-4-nitroanilide
0.29 - 0.51
succinyl-Ser-Pro-Phe-4-nitroanilide
0.25 - 0.28
succinyl-Thr-Pro-Phe-4-nitroanilide
0.88 - 1.1
succinyl-Val-Pro-Leu-4-nitroanilide
0.53 - 1.2
succinyl-Val-Pro-Met-4-nitroanilide
0.093 - 0.12
succinyl-Val-Pro-Phe-4-nitroanilide
0.025 - 0.048
succinyl-Val-Pro-Pro-Phe-SCH2C6H5
-
0.24 - 1.6
succinyl-Val-Pro-Trp-4-nitroanilide
0.084 - 0.17
succinyl-Val-Pro-Tyr-4-nitroanilide
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.93 - 19.3
Ala-Ala-Pro-Leu-4-nitroanilide
0.098 - 23
Ala-Ala-Pro-Met-4-nitroanilide
0.028 - 143
Ala-Ala-Pro-Phe-4-nitroanilide
65 - 149
angiotensin I
1.19
angiotensin II
Mesocricetus auratus
-
-
24.7 - 25.6
Big endothelin-1
46
DRVWIHOLHL
Homo sapiens
-
-
-
160
DRVWIHPFHL
Homo sapiens
-
-
210
DRVWIHPWHL
Homo sapiens
-
-
13
H2N(CH2)5CO-Ala-Ala-Pro-Phe-4-nitroanilide
Rattus norvegicus
-
-
10
methoxysuccinyl-Ala-Ala-Pro-Phe-4-nitroanilide
Rattus norvegicus
-
-
6.7
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide
Homo sapiens
-
-
2.5
succinyl-Ala-Ala-Pro-Met-4-nitroanilide
Homo sapiens
-
-
1.25 - 65
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide
38 - 51
succinyl-Ala-Pro-Phe-4-nitroanilide
17
succinyl-Ala-Val-Pro-Phe-4-nitroanilide
Rattus norvegicus
-
-
4.7
succinyl-epsilon-(2-picolinyl)Lys-Pro-Phe-4-nitroanilide
Rattus norvegicus
-
-
-
86 - 480
succinyl-epsilon-(2-picolinyl)Lys-Val-Pro-Phe-4-nitroanilide
-
56 - 86
succinyl-Gln-Pro-Phe-4-nitroanilide
9.2 - 61
succinyl-Glu-Pro-Phe-4-nitroanilide
53 - 68
succinyl-Glu-Val-Pro-Phe-4-nitroanilide
2.5 - 3.6
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-4-nitroanilide
12.6 - 17.8
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-thiobenzyl ester
37 - 77
succinyl-Leu-Pro-Phe-4-nitroanilide
19 - 79
succinyl-Leu-Val-Pro-Phe-4-nitroanilide
14 - 32
succinyl-Lys-Pro-Phe-4-nitroanilide
58 - 66
succinyl-Lys-Val-Pro-Phe-4-nitroanilide
25 - 100
succinyl-Met-Pro-Phe-4-nitroanilide
25 - 53
succinyl-Met-Val-Pro-Phe-4-nitroanilide
7.1 - 10
succinyl-Phe-Ala-Phe-4-nitroanilide
23
succinyl-Phe-epsilon-(2-picolinyl)Lys-4-nitroanilide
Rattus norvegicus
-
-
-
3.9 - 25
succinyl-Phe-Gln-Phe-4-nitroanilide
0.9 - 8.4
succinyl-Phe-Glu-Phe-4-nitroanilide
7.5 - 19
succinyl-Phe-Leu-Phe-4-nitroanilide
18
succinyl-Phe-Lys-Phe-4-nitroanilide
Rattus norvegicus
-
-
5.9 - 8.2
succinyl-Phe-Met-Phe-4-nitroanilide
17 - 28
succinyl-Phe-Pro-Phe-4-nitroanilide
11 - 19
succinyl-Phe-Pro-Thr-Phe-4-nitroanilide
5.4 - 6.2
succinyl-Phe-Ser-Phe-4-nitroanilide
9.3 - 10
succinyl-Phe-Thr-Phe-4-nitroanilide
4 - 15
succinyl-Phe-Val-Phe-4-nitroanilide
24 - 56
succinyl-Phe-Val-Pro-Phe-4-nitroanilide
20 - 38
succinyl-Ser-Pro-Phe-4-nitroanilide
38 - 120
succinyl-Thr-Pro-Phe-4-nitroanilide
13 - 21
succinyl-Val-Pro-Leu-4-nitroanilide
1.2 - 8.7
succinyl-Val-Pro-Met-4-nitroanilide
57 - 75
succinyl-Val-Pro-Phe-4-nitroanilide
130 - 400
succinyl-Val-Pro-Pro-Phe-SCH2C6H5
-
5.6 - 8.4
succinyl-Val-Pro-Trp-4-nitroanilide
5.5 - 19
succinyl-Val-Pro-Tyr-4-nitroanilide