Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,3,4,6-pentagalloyl glucopyranoside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
1,2,3,6-tetragalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
1,2,3-trigalloyl glucopyranoside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
1,2,6-trigalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
1,2,6-trigalloyl glucopyranoside | from Euphorbia helioscopia, specific, noncompetitive, and strong inhibition | Homo sapiens | |
1,3,6-trigalloyl alloside | specific, noncompetitive, and strong inhibition | Homo sapiens | |
acetonyl geraniin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
bixanin | specific and noncompetitive inhibition | Homo sapiens | |
corilagin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
elaeocarpusin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
euphorscopin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
geraniin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
ginkgolic acid | - |
Homo sapiens | |
helioscopin B | specific, noncompetitive, and strong inhibition | Homo sapiens | |
helioscopinin A | specific, noncompetitive, and strong inhibition | Homo sapiens | |
helioscopinin B | specific, noncompetitive, and strong inhibition | Homo sapiens | |
jolkinin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
kinapsin-24 | - |
Homo sapiens | |
macranganin | from Euphorbia fisheriana, specific, noncompetitive, and strong inhibition | Homo sapiens | |
additional information | at least 3 galloyl groups are required for strong inhibition activity by Euphorbiaceae plants, poor inhibition by 1-galloyl glucopyranoside, 1,6-digalloyl glucopyranoside, 2,6-digalloyl glucopyranoside, 2-galloyl galactose, 6-galloyl-1-O-(4-gallate)-glucopyranoside, 6-galloyl-1-O-(phloroglucinol)-glucopyranoside, gallic acid, furosin, anthricin, gomisin A, tigloyl gomisin, 8-C-(glucopyranosyl)-kaempferol, 3-O-galloyl shikimate, 4-O-galloyl shikimate, 3-O-(2-galloyl-glucopyranosyl)-quercetin, quercetin-3-O-glucopyranoside, alpha-viniferin, 5-O-galloylquininc acid, and shizarin, overview | Homo sapiens | |
N-benzyloxycarbonyl-L-prolyl-L-prolinal | i.e. Z-Pro-prolinal | Homo sapiens | |
rugosin E | from Euphorbia supina, specific, noncompetitive, and strong inhibition | Homo sapiens | |
staurosporine | - |
Homo sapiens | |
supinanin | specific, noncompetitive, and strong inhibition | Homo sapiens | |
teracatain | specific, noncompetitive, and strong inhibition | Homo sapiens | |
Z-Pro-prolinal | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | of Alzheimer's disease patients, showing high enzyme expression levels, and healthy individuals | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-Ala-Ala-Ala-4-nitroanilide | - |
Homo sapiens | N-succinyl-Ala-Ala-Ala + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prolyl endopeptidase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000004 | - |
1,3,6-trigalloyl alloside | - |
Homo sapiens | |
0.0000046 | - |
euphorscopin | - |
Homo sapiens | |
0.0000094 | - |
rugosin E | - |
Homo sapiens | |
0.0000171 | - |
geraniin | - |
Homo sapiens | |
0.0000184 | - |
elaeocarpusin | - |
Homo sapiens | |
0.0000194 | - |
1,2,6-trigalloyl glucopyranoside | - |
Homo sapiens | |
0.0000272 | - |
1,2,3,4,6-pentagalloyl glucopyranoside | - |
Homo sapiens | |
0.000074 | - |
acetonyl geraniin | - |
Homo sapiens | |
0.000091 | - |
supinanin | - |
Homo sapiens | |
0.000098 | - |
helioscopinin B | - |
Homo sapiens | |
0.000102 | - |
helioscopinin A | - |
Homo sapiens | |
0.000129 | - |
helioscopin B | - |
Homo sapiens | |
0.000194 | - |
1,2,6-trigalloyl glucopyranoside | - |
Homo sapiens | |
0.000203 | - |
1,2,6-trigalloyl alloside | - |
Homo sapiens | |
0.000212 | - |
corilagin | - |
Homo sapiens | |
0.000405 | - |
1,2,3,6-tetragalloyl alloside | - |
Homo sapiens | |
0.000441 | - |
macranganin | - |
Homo sapiens | |
0.00079 | - |
jolkinin | - |
Homo sapiens | |
0.001717 | - |
teracatain | - |
Homo sapiens | |
0.00249 | - |
1,2,3-trigalloyl glucopyranoside | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000267 | - |
- |
Homo sapiens | rugosin E | |
0.0000314 | - |
- |
Homo sapiens | 1,2,6-trigalloyl glucopyranoside | |
0.0000426 | - |
- |
Homo sapiens | macranganin | |
0.0000516 | - |
- |
Homo sapiens | Z-Pro-prolinal | |
0.00062 | - |
- |
Homo sapiens | ginkgolic acid | |
0.00077 | - |
- |
Homo sapiens | staurosporine | |
0.00114 | - |
- |
Homo sapiens | kinapsin-24 | |
0.0231 | - |
- |
Homo sapiens | bixanin |