Application | Comment | Organism |
---|---|---|
pharmacology | enzyme is a target for the development of antineoplastic agents | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
J series prostaglandins | inhibition of the enzyme is involved in disruption of the proteasome pathway and leads to apoptosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyubiquitin + H2O | Homo sapiens | disassembly of polyubiquitin, terminal step of the proteasome pathway, scheme | ubiquitin | - |
? | |
polyubiquitin + H2O | Homo sapiens | inhibition by prostaglandins of the J series leads to accumulation of polyubiquitins of MW around 250 kDa | ubiquitin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyubiquitin + H2O | dissambly of polyubiquitin | Homo sapiens | ubiquitin | - |
? | |
polyubiquitin + H2O | disassembly of polyubiquitin, terminal step of the proteasome pathway, scheme | Homo sapiens | ubiquitin | - |
? | |
polyubiquitin + H2O | inhibition by prostaglandins of the J series leads to accumulation of polyubiquitins of MW around 250 kDa | Homo sapiens | ubiquitin | - |
? |