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Literature summary for 3.4.19.1 extracted from

  • Sherriff, R.M.; Broom, M.F.; Chadwick, V.S.
    Isolation and purification of N-formylmethionine aminopeptidase from rat intestine (1992), Biochim. Biophys. Acta, 1119, 275-280.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Rattus norvegicus
Cu2+
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
N-acetyl-Met-Leu
-
Rattus norvegicus
0.04
-
formylmethionine-Leu
-
Rattus norvegicus
0.06
-
formylmethionine-Val
-
Rattus norvegicus
0.16
-
N-acetyl-Met-Leu-Phe
-
Rattus norvegicus
0.18
-
formylmethionine-Leu-Phe
-
Rattus norvegicus
0.22
-
formylmethionine-Leu-Tyr
-
Rattus norvegicus
0.63
-
formylmethionine-Phe
-
Rattus norvegicus
0.71
-
formylmethionine-Trp
-
Rattus norvegicus
1.7
-
formylmethionine-beta-naphthylamide
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cl- activates Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
320000 340000 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestine mucosal epithelium Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
12.86
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formylmethionine-beta-naphthylamide + H2O
-
Rattus norvegicus formylmethionine + beta-naphthylamine
-
?
formylmethionine-Leu + H2O
-
Rattus norvegicus formylmethionine + Leu
-
?
formylmethionine-Leu-Phe + H2O
-
Rattus norvegicus ?
-
?
formylmethionine-Leu-Tyr + H2O
-
Rattus norvegicus ?
-
?
formylmethionine-Phe + H2O
-
Rattus norvegicus formylmethionine + Phe
-
?
formylmethionine-Trp + H2O
-
Rattus norvegicus formylmethionine + Trp
-
?
formylmethionine-Val + H2O
-
Rattus norvegicus formylmethionine + Val
-
?
additional information specific for N-terminal acylmethionine residues Rattus norvegicus ?
-
?
N-acetyl-Met-Leu + H2O
-
Rattus norvegicus ?
-
?
N-acetyl-Met-Leu-Phe + H2O
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 82000-84000, SDS-PAGE Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.17
-
formylmethionine-Leu
-
Rattus norvegicus
5.45
-
N-acetyl-Met-Leu
-
Rattus norvegicus
5.94
-
formylmethionine-Val
-
Rattus norvegicus
12.3
-
formylmethionine-Leu-Phe
-
Rattus norvegicus
15.5
-
formylmethionine-Leu-Tyr
-
Rattus norvegicus
27.1
-
N-acetyl-Met-Leu-Phe
-
Rattus norvegicus
31.3
-
formylmethionine-Trp
-
Rattus norvegicus
70.2
-
formylmethionine-Phe
-
Rattus norvegicus
76.4
-
formylmethionine-beta-naphthylamide
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9 hydrolysis of formylmethionine-beta-naphthylamide or Met-Met-Leu-Phe Rattus norvegicus