Literature summary for 3.4.17.10 extracted from

Xiao, L.; Yang, X.; Loh, Y.P.
Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants (2019), Front. Neurosci., 13, 243 .

Search for more literature for 3.4.17.10

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16870	-	-
Mus musculus	Q00493	-	-

Synonyms

Synonyms	Comment	Organism
CPE-NFalpha1	-	Mus musculus
CPE-NFalpha1	-	Homo sapiens
neurotrophic factor-alpha1	-	Mus musculus
neurotrophic factor-alpha1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme cleaves C-terminal basic amino acids from prohormone intermediates to produce mature peptide hormones and neuropeptides in the endocrine and central nervous systems. It also plays a critical role in prohormone sorting and secretory vesicle transportation. The enzyme exerts multiple non-enzymatic physiological roles in maintaining normal central nervous system function and in neurodevelopment. This includes potent neuroprotective and anti-depressant activities, as well as stem cell differentiation functions. In addition, N-terminal truncated variants of the enzyme regulate expression of important neurodevelopmental genes	Mus musculus
physiological function	the enzyme cleaves C-terminal basic amino acids from prohormone intermediates to produce mature peptide hormones and neuropeptides in the endocrine and central nervous systems. It also plays a critical role in prohormone sorting and secretory vesicle transportation. The enzyme exerts multiple non-enzymatic physiological roles in maintaining normal central nervous system function and in neurodevelopment. This includes potent neuroprotective and anti-depressant activities, as well as stem cell differentiation functions. In addition, N-terminal truncated variants of the enzyme regulate expression of important neurodevelopmental genes	Homo sapiens
physiological function	the enzyme plays a critical role in prohormone sorting and secretory vesicle transportation	Mus musculus
physiological function	the enzyme plays a critical role in prohormone sorting and secretory vesicle transportation	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)