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Literature summary for 3.4.17.10 extracted from

  • Ji, L.; Wu, H.T.; Qin, X.Y.; Lan, R.
    Dissecting carboxypeptidase E properties, functions and pathophysiological roles in disease (2017), Endocr. Connect., 6, R18-R38 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.10

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms Mus musculus 16020
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membrane the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms Homo sapiens 16020
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soluble the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms Mus musculus
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soluble the enzyme is produced from pro-carboxypeptidase E and exists in soluble and membrane forms Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens P16870
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Mus musculus Q00493
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General Information

General Information Comment Organism
malfunction in two types of carboxypeptidase E mutant mice, Cpefat/Cpefat and Cpe knockout, loss of normal carboxypeptidase E leads to a lot of disorders, including diabetes, hyperproinsulinemia, low bone mineral density and deficits in learning and memory Mus musculus
malfunction in two types of carboxypeptidase E mutant mice, Cpefat/Cpefat and Cpe knockout, loss of normal carboxypeptidase E leads to a lot of disorders, including diabetes, hyperproinsulinemia, low bone mineral density and deficits in learning and memory Homo sapiens
physiological function the enzyme is involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues, and in the nervous system. Membrane carboxypeptidase E mediates the targeting of prohormones to the regulated secretory pathway, while soluble carboxypeptidase E acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. Carboxypeptidase E also participates in protein internalization, vesicle transport and regulation of signaling pathways Mus musculus
physiological function the enzyme is involved in the biosynthesis of a wide range of neuropeptides and peptide hormones in endocrine tissues, and in the nervous system. Membrane carboxypeptidase E mediates the targeting of prohormones to the regulated secretory pathway, while soluble carboxypeptidase E acts as an exopeptidase and cleaves C-terminal basic residues from peptide intermediates to generate bioactive peptides. Carboxypeptidase E also participates in protein internalization, vesicle transport and regulation of signaling pathways Homo sapiens