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Literature summary for 3.4.14.2 extracted from
- Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases (2000), Biochim. Biophys. Acta, 1479, 15-31.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala-PSI[CS-N]-pyrrolidine | competitive | Homo sapiens |  |
| Ala-PSI[CS-N]-pyrrolidine | competitive | Sus scrofa | |
| Ala-PSI[CS-N]-thiazolidine | competitive | Homo sapiens | |
| Ala-PSI[CS-N]-thiazolidine | competitive | Sus scrofa | |
| Ala-pyrrolidine | competitive | Homo sapiens | |
| Ala-pyrrolidine | competitive | Sus scrofa | |
| Ala-thiazolidine | competitive | Homo sapiens | |
| Ala-thiazolidine | competitive | Sus scrofa | |
| Ile-PSI[CS-N]-pyrrolidine | competitive | Homo sapiens | |
| Ile-PSI[CS-N]-pyrrolidine | competitive | Sus scrofa | |
| Ile-PSI[CS-N]-thiazolidine | competitive | Homo sapiens | |
| Ile-PSI[CS-N]-thiazolidine | competitive | Sus scrofa | |
| Ile-pyrrolidine | competitive | Homo sapiens | |
| Ile-pyrrolidine | competitive | Sus scrofa | |
| Ile-thiazolidine | competitive | Homo sapiens | |
| Ile-thiazolidine | competitive | Sus scrofa | |
| additional information | isomerization of the thiazolidine derivatives | Homo sapiens | |
| additional information | isomerization of the thiazolidine derivatives | Sus scrofa | |
| Phe-PSI[CS-N]-pyrrolidine | competitive | Homo sapiens | |
| Phe-PSI[CS-N]-pyrrolidine | competitive | Sus scrofa | |
| Phe-PSI[CS-N]-thiazolidine | competitive | Homo sapiens | |
| Phe-PSI[CS-N]-thiazolidine | competitive | Sus scrofa | |
| Phe-pyrrolidine | competitive | Homo sapiens | |
| Phe-pyrrolidine | competitive | Sus scrofa | |
| Phe-thiazolidine | competitive | Homo sapiens | |
| Phe-thiazolidine | competitive | Sus scrofa | |
| Val-PSI[CS-N]-pyrrolidine | competitive | Homo sapiens | |
| Val-PSI[CS-N]-pyrrolidine | competitive | Sus scrofa | |
| Val-PSI[CS-N]-thiazolidine | competitive | Homo sapiens | |
| Val-PSI[CS-N]-thiazolidine | competitive | Sus scrofa | |
| Val-pyrrolidine | competitive | Homo sapiens | |
| Val-pyrrolidine | competitive | Sus scrofa | |
| Val-thiazolidine | competitive | Homo sapiens | |
| Val-thiazolidine | competitive | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.25 | - |
Gly-Pro-4-nitroanilide | pH 5.5, 30°C | Homo sapiens | |
| 0.59 | - |
Gly-Pro-4-nitroanilide | pH 5.5, 30°C | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosomal | - |
Homo sapiens | - |
- |
| lysosome | - |
Sus scrofa | 5764 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro-4-nitroanilide + H2O | specific for proline | Homo sapiens | Gly-Pro + 4-nitroaniline | - |
? | |
| Gly-Pro-4-nitroanilide + H2O | specific for proline | Sus scrofa | Gly-Pro + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidyl peptidase II | - |
Homo sapiens |
| dipeptidyl peptidase II | - |
Sus scrofa |
| DP II | - |
Homo sapiens |
| DP II | - |
Sus scrofa |
| More | enzyme belongs to the Pro-X carboxypeptidase family S28 | Homo sapiens |
| More | enzyme belongs to the Pro-X carboxypeptidase family S28 | Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
| 30 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
assay at | Homo sapiens |
| 5.5 | - |
assay at | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00028 | - |
Ala-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0006 | - |
Phe-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.00065 | - |
Ala-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.00066 | - |
Val-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0009 | - |
Val-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.00091 | - |
Ile-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0011 | - |
Ile-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0014 | - |
Ala-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0016 | - |
Phe-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0032 | - |
Phe-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0033 | - |
Ala-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0035 | - |
Phe-PSI[CS-N]-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0044 | - |
Ala-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0048 | - |
Ile-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.005 | - |
Val-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0052 | - |
Ala-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0057 | - |
Val-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0071 | - |
Ile-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0073 | - |
Phe-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0077 | - |
Val-thiazolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0082 | - |
Val-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0082 | - |
Ile-thiazolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0101 | - |
Ile-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0116 | - |
Phe-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0139 | - |
Phe-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0159 | - |
Phe-PSI[CS-N]-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0218 | - |
Ala-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.023 | - |
Ala-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0247 | - |
Ile-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0259 | - |
Val-pyrrolidine | pH 5.5, 30°C | Sus scrofa | |
| 0.0267 | - |
Val-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
| 0.0302 | - |
Ile-pyrrolidine | pH 5.5, 30°C | Homo sapiens | |
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