Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | HL-60 cells and differentiated neutrophil-like cells show active CatC in cytoplasmic granules | Homo sapiens | 5737 | - |
Golgi apparatus | mainly located in the Golgi of granule-free undifferentiated PLB-985 cells | Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P53634 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
PLB-985 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gly-Phe-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gly-Phe + 7-amino-4-methylcoumarin | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | the maturation of proCatC obeys a multistep mechanism that can be entirely managed by CatS in neutrophilic precursor cells. CatS inhibition by a cell-permeable inhibitor abrogates the release of the heavy and light chains from proCatC and blocks 80% of CatC activity. Under these conditions, the activity of neutrophil serine proteases is not abolished in precursor cell cultures | Homo sapiens |