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Literature summary for 3.2.1.62 extracted from

  • Jacob, R.; Weiner, J.R.; Stadge, S.; Naim, H.Y.
    Additional N-glycosylation and its impact on the folding of intestinal lactase-phlorizin hydrolase (2000), J. Biol. Chem., 275, 10630-10637.
    View publication on PubMed
Search for more literature for 3.2.1.62

Cloned(Commentary)

Cloned (Comment) Organism
expression of mutants in Cos-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D1711N introduction of a glycosylation site, reduced transport rate to the plasma membrane Homo sapiens
D1711N introduction of potential N-glycosylation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency Homo sapiens
I1697N introduction of a glycosylation site, reduced transport rate to the plasma membrane Homo sapiens
I1697N introduction of potential N-glycosylation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency Homo sapiens
P1743S introduction of a glycosylation site, reduced transport rate to the plasma membrane Homo sapiens
P1743S introduction of potential N-glycosylation site, no enzymic activity, probably due to altered protein folding pattern and reduced dimerization efficiency Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane transfected Cos-1 cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O Homo sapiens
-
 D-galactose + beta-D-glucose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O
-
 Homo sapiens D-galactose + beta-D-glucose
-
 ?

Subunits

Subunits Comment Organism
More region LAC236 between R1647 and T1882 is implicated in the dimerization processof pro-enzyme Homo sapiens