Literature summary for 3.2.1.122 extracted from

Rajan, S.S.; Yang, X.; Collart, F.; Yip, V.L.Y.; Withers, S.G.; Varrot, A.; Thompson, J.; Davies, G.J.; Anderson, W.F.
Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+-dependent phospho-alpha-glucosidase from Bacillus subtilis (2004), Structure, 12, 1619-1629.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Mn2+	-	Bacillus subtilis

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Bacillus subtilis

Crystallization (Commentary)

Crystallization (Comment)	Organism
in the presence and absence of its known ligands, resolution at 2.05 A	Bacillus subtilis

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	essential for activity	Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
maltose 6'-phosphate + H2O	Bacillus subtilis	-	D-glucose + D-glucose 6-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	P54716	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Bacillus subtilis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
maltose 6'-phosphate + H2O	-	Bacillus subtilis	D-glucose + D-glucose 6-phosphate	-	?

Subunits

Subunits	Comment	Organism
tetramer	alpha4, crystal structure	Bacillus subtilis

Synonyms

Synonyms	Comment	Organism
6-phospho-alpha-glucosidase	-	Bacillus subtilis
GlvA	-	Bacillus subtilis
phospho-alpha-glucosidase	-	Bacillus subtilis

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Bacillus subtilis

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Release 2023.1 (January 2023)