Literature summary for 3.1.8.1 extracted from

Arslan, M.; Gencer, N.; Arslan, O.; Guler, O.O.
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity (2012), J. Enzyme Inhib. Med. Chem., 27, 72272-9.

Search for more literature for 3.1.8.1

Inhibitors

Inhibitors	Comment	Organism	Structure
atropine sulfate	most potent and significant inhibition, IC50 of 0.041 mg/ml	Bos taurus
dexamethasone	most potent and significant inhibition, IC50 of 0.014 mg/ml	Bos taurus
furosemid	most potent and significant inhibition, IC50 of 0.235 mg/ml	Bos taurus
gentamicin sulfate	IC50 of 3.784 mg/ml	Bos taurus
metamizole sodium	IC50 of 26.777 mg/ml	Bos taurus
Oxytocin	IC50 of 507.72 mg/ml	Bos taurus
sulfadoxine-trimethoprim	IC50 of 15.636 mg/ml	Bos taurus
toldimfos sodium	IC50 of 11.08 mg/ml	Bos taurus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	a calcium-associated enzyme	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
ammonium sulfate precipitation and Sepharose-4B-L-tyrosine-9-aminophenanthrene column chromatography	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Bos taurus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00711	-	crude enzyme, at pH 8.0, 37°C	Bos taurus
14.92	-	after 1690fold purification, at pH 8.0, 37°C	Bos taurus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
paraoxon + H2O	-	Bos taurus	4-nitrophenol + diethyl phosphate	-	?

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Release 2023.1 (January 2023)