Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chloramphenicol | 50% inhibition at 0.0309 mg/ml; inhibits the extracellular and the hepatoma cell enzyme, IC50, overview | Homo sapiens | |
clarithromycin | 50% inhibition at 5.121 mg/ml; inhibits the extracellular and the hepatoma cell enzyme, IC50, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
paraoxon | serum enzyme, pH 8.0, 37°C | Homo sapiens | |
4.16 | - |
paraoxon | pH 8.0, 37°C | Homo sapiens | |
4.16 | - |
paraoxon | liver enzyme, pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
isoform hPON1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
native extracellular serum enzyme by ammonium sulfate fractionation and hydrophobic interaction chromatography on a L-tyrosine and 1-naphthylamine containing resin to homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Hep-G2 cell | hepatoma cell line | Homo sapiens | - |
liver | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
227.3 | - |
pH 8.0, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 43000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase | - |
Homo sapiens |
PON1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |