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Literature summary for 3.1.4.12 extracted from

  • Schramm, M.; Herz, J.; Haas, A.; Kroenke, M.; Utermoehlen, O.
    Acid sphingomyelinase is required for efficient phago-lysosomal fusion (2008), Cell. Microbiol., 10, 1839-1853.
    View publication on PubMed
Search for more literature for 3.1.4.12

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome localizes to the lumen of endosomes Mus musculus 5768
-
lysosome localizes to the lumen of lysosomes Mus musculus 5764
-
phagosome localizes to the lumen of phagosomes Mus musculus
-
-
plasma membrane localizes to the outer leaflet of the plasma membrane Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ASMase activity is required for an efficient fusion of late phagosomes with lysosomes including the efficient transfer of lysosomal hydrolases into phagosomes containing Listeria monocytogenes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ASMase activity is required for an efficient fusion of late phagosomes with lysosomes including the efficient transfer of lysosomal hydrolases into phagosomes containing Listeria monocytogenes Mus musculus ?
-
 ?
sphingomyelin + H2O
-
 Mus musculus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
 Mus musculus
aSMase
-
 Mus musculus