Literature summary for 3.1.4.11 extracted from

van Veen, M.; Mans, L.A.; Matas-Rico, E.; van Pelt, J.; Perrakis, A.; Moolenaar, W.H.; Haramis, A.G.
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish (2018), Int. J. Biochem. Cell Biol., 94, 71-78 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	zebrafish Gdpd5 orthologues localize to the plasma membrane where they show catalytic activity against GPI-anchored glypican-6	Danio rerio	5886	-

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	E9QG52	isoform Gdpd5a	-
Danio rerio	X1WHY1	isoform Gdpd5b	-
Homo sapiens	Q8WTR4	-	-

Synonyms

Synonyms	Comment	Organism
GDE2	-	Homo sapiens
GDE2	-	Danio rerio
GDPD5	-	Danio rerio
glycerophosphodiester phosphodiesterase domain-containing 5a	-	Danio rerio
glycerophosphodiester phosphodiesterase domain-containing 5b	-	Danio rerio

General Information

General Information	Comment	Organism
physiological function	knockdown of both isoforms Gdpd5a and Gdpd5b in zebrafish embryos leads to developmental defects, particularly impaired motility and reduced pancreas differentiation. Exogenous expression of human GDE2 similarly leads to developmental defects. Expression of human GDE2 restores insulin expression in Gdpd5a-depleted zebrafish embryos	Homo sapiens
physiological function	knockdown of both isoforms Gdpd5a and Gdpd5b in zebrafish embryos leads to developmental defects, particularly impaired motility and reduced pancreas differentiation. Exogenous expression of human GDE2 similarly leads to developmental defects. Expression of human GDE2 restores insulin expression in Gdpd5a-depleted zebrafish embryos	Danio rerio

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Release 2023.1 (January 2023)