Cloned (Comment) | Organism |
---|---|
expression of sc1 in Saccharomyces cerevisiae DELTAisc1 mutant | Cryptococcus neoformans |
Protein Variants | Comment | Organism |
---|---|---|
D114A | catalytically inactive Isc1 mutant | Cryptococcus neoformans |
K119A | catalytically inactive Isc1 mutant | Cryptococcus neoformans |
additional information | Isc1, site-directed mutagenesis of the P-loop-like domain | Cryptococcus neoformans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cryptococcus neoformans | Isc1 only exerts IPC-PLC activity | ? | - |
? | |
additional information | Cryptococcus neoformans H99 | Isc1 only exerts IPC-PLC activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | - |
serotype C | - |
Cryptococcus neoformans | - |
var. gattii serotype B | - |
Cryptococcus neoformans | - |
var. grubii serotype A | - |
Cryptococcus neoformans H99 | - |
serotype C | - |
Cryptococcus neoformans H99 | - |
var. gattii serotype B | - |
Cryptococcus neoformans H99 | - |
var. grubii serotype A | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Isc1 only exerts IPC-PLC activity | Cryptococcus neoformans | ? | - |
? | |
additional information | Isc1 only exerts IPC-PLC activity | Cryptococcus neoformans H99 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol phosphosphingolipid-phospholipase C | - |
Cryptococcus neoformans |
IPC-PLC | - |
Cryptococcus neoformans |
Isc1 | - |
Cryptococcus neoformans |
General Information | Comment | Organism |
---|---|---|
physiological function | Isc1 regulates the level of complex sphingolipids and certain species of phytoceramide, especially when fungal cells are exposed to acidic stress. Either the enzyme Isc1 P-loop is not involved in the substrate recognition or that it is not sufficient to discriminate between phosphoinositide and sphingomyelin | Cryptococcus neoformans |