Protein Variants | Comment | Organism |
---|---|---|
additional information | creation of deltaplc1 deletion mutant. Deltaplc1 fails to grow at 37°C and exhibits slightly slower, but similar growth at 25°C and 30°C. PLC1 is essential for high-temperature growth and melanin production. PLC1, but not PLC2, is essential for all of these phenotypes and that the absence of the Plc1 enzyme in deltaplc1 compromises activation of the PKC/MAPK pathway. PLC1 is essential for cell wall integrity | Cryptococcus neoformans var. grubii |
additional information | creation of deltaplc2 deletion mutant. PLC2 is not essential for all phenotypes | Cryptococcus neoformans var. grubii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inactive analogue control (U73343) has no antifungal activity against Cryptococcus neoformans; inactive analogue control (U-73343) has no antifungal activity against Cryptococcus neoformans. Deltaplc1 is hypersusceptible to flucytosine, azoles and amphotericin B, but not to caspofungin | Cryptococcus neoformans var. grubii | |
U-73122 | PLC inhibitor, inhibits growth of Cryptococcus neoformans; PLC inhibitor, inhibits growth of Cryptococcus neoformans | Cryptococcus neoformans var. grubii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans var. grubii | B4XX94 | - |
- |
Cryptococcus neoformans var. grubii | B4XX95 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-specific phospholipase C | - |
Cryptococcus neoformans var. grubii |
PI-PLC | - |
Cryptococcus neoformans var. grubii |
PLC1 | - |
Cryptococcus neoformans var. grubii |
PLC2 | - |
Cryptococcus neoformans var. grubii |