Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme acting on PtdIns is Ca2+-dependent, in contrary to that acting on PtdIns(4,5)P2 which remains active in the presence of 10 mM EGTA | Felis catus | |
Carbachol | small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect | Felis catus | |
dopamine | small stimulatory effect of about 30% on the enzyme acting on PtdIns(4,5)P2. GTPgammaS enhances this effect | Felis catus | |
GTPgammaS | PtdIns(4,5)P2-PLC is stimulated by GTPgammaS. Enzyme acting on PtdIns is not activated by GTPgS | Felis catus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Felis catus | the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Felis catus | - |
adult | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carotid body | the carotid bodies (CB) are a paired chemoreceptor organ located at the bifurcation of the common carotid arteries | Felis catus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Felis catus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
additional information | the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1 | Felis catus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PtdIns(4,5)P2-PLC | - |
Felis catus |