Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | above 0.1 mM | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, maximal activity at 100 nM | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hepatoma cell | rapidly growing hepatoma 3924A | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown | Rattus norvegicus | ? | - |
? | |
phosphatidylinositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | 5.5 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 7.5 | pH 4.5: about 25% of maximal activity, pH 7.5: about 55% of maximal activity, hydrolysis of phosphatidylinositol 4,5-diphosphate | Rattus norvegicus |