Literature summary for 3.1.4.1 extracted from

Ruecker, B.; Almeida, M.E.; Libermann, T.A.; Zerbini, L.F.; Wink, M.R.; Sarkis, J.J.
Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat heart left ventricle (2007), Mol. Cell. Biochem., 306, 247-254.

Search for more literature for 3.1.4.1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	not inhibitory: levamisole, sodium azide, gadolinium chloride	Rattus norvegicus
suramin	0.25 mM, about 46% inhibition	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.091	-	p-nitrophenylthymidine 5'-phosphate	pH 8.9, 37°C	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoform ecto-nucleotide pyrophosphatase/phosphodiesterase	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	heart left ventricle, expression of isoforms NPP2 and NPP3, not NPP1. NPP3 shows the highest abundance	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p-nitrophenylthymidine 5'-phosphate + H2O	-	Rattus norvegicus	5'-TMP + p-nitrophenol	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.9	-	-	Rattus norvegicus

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Release 2023.1 (January 2023)