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Literature summary for 3.1.1.47 extracted from

  • Marques, M.; Pei, Y.; Southall, M.D.; Johnston, J.M.; Arai, H.; Aoki, J.; Inoue, T.; Seltmann, H.; Zouboulis, C.C.; Travers, J.B.
    Identification of platelet-activating factor acetylhydrolase II in human skin (2002), J. Invest. Dermatol., 119, 913-919.
    View publication on PubMed
Search for more literature for 3.1.1.47

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of isozyme II in HaCaT cells, protects cells against apoptosis induced by tert-butylhydroperoxid, C2-ceramide or ultraviolet B radiation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
intracellular
-
 Homo sapiens 5622
-
membrane
-
 Homo sapiens 16020
-
additional information treatment of epidermal cells with tert-butyl-hydroperoxide or ultraviolet B radiation results in isozyme II translocation from the cytosol to membranes Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor, the enzyme converts the proinflammatory autocoid platelet-activating factor PAF into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme II
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
keratinocyte epidermal, isozyme II, lower amount compared to sebaceous gland Homo sapiens
-
sebaceous gland isozyme II, high amount Homo sapiens
-
skin isozyme II Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, the enzyme converts the proinflammatory autocoid platelet-activating factor PAF into biologically inactive lyso-PAF, by the removal of the sn-2 acetyl group Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
PAF-AH II
-
 Homo sapiens
platelet-activating factor acetylhydrolase II
-
 Homo sapiens