Application | Comment | Organism |
---|---|---|
diagnostics | the enzyme is a positive risk factor for coronary disease and measurements of its amount may contribute to the prediction of coronary heart disease risk, especially in individuals with low LDL cholesterol levels | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene maps to chromosome 6q12.p21.1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
V279F | naturally occurring mutantion, ecspecially in Japanese population, loss of enzyme activity, associated with increased risk of stroke and of coronary artery disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | plasma | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | secretory isozyme is Ca2+-independent | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
14000 | - |
x * 14000, secretory isozyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | i.e. platelet-activation factor | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | Homo sapiens | the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation is essential | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery wall | - |
Homo sapiens | - |
macrophage | increased enzyme expression in artheriosclerosis | Homo sapiens | - |
additional information | wide tissue distribution | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
additional information | lipoprotein-associated enzyme does not hydrolyse native phospholipids | Homo sapiens | ? | - |
? | |
additional information | the plasma isozyme is associated with LDL, 80%, and HDL, 15-20%, and VLDL, below 5%, particles, where it seems to be independently regulated and to have distinct roles in artherosclerosis, LDL-associated enzyme has a protective role in artheriosclerosis, regulation of lipoprotein-associated enzyme in vivo, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 14000, secretory isozyme | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lipoprotein-associated phospholipase A2 | - |
Homo sapiens |
Lp-PLA2 | - |
Homo sapiens |
PAF acetylhydrolase | - |
Homo sapiens |
platelet-activating factor acetylhydrolase | - |
Homo sapiens |